{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sardarabadi P"],"funding":["National Science and Technology Council","Interdisciplinary Integration of Advanced Medical Technology (Medical+X) Program"],"pagination":["4354-4367"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11758792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(3)"],"pubmed_abstract":["Interleukin 6 (IL-6), produced by immune cells, is crucial in promoting T cell trafficking to infection and inflammation sites, influencing various physiological and pathological processes. Concentrations of IL-6 and other cytokines and chemokines can influence T cell differentiation and activation. Understanding the dual faces of IL-6 within the tumor microenvironment is crucial to understanding its role. A flow-based microsystem was designed to investigate CD4<sup>+</sup> T cell activation in response to different IL-6 gradients in an under-control 3D culture. The study found that cancer cells' response to varying IL-6 concentrations was dynamic and dose-sensitive, with immune cell migration rates showing sensitivity to the IL-6 gradient. A549 cell expansion increases gradually and time-"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Investigating T Cell Immune Dynamics and IL-6's Duality in a Microfluidic Lung Tumor Model."],"pmcid":["PMC11758792"],"funding_grant_id":["NSTC 112-2223-E-007-011","NSTC 113-2221-E-007-076","113QF003E1"],"pubmed_authors":["Liu CH","Sardarabadi P","Lee KY","Sun WL","Kojabad AA"],"additional_accession":[]},"is_claimable":false,"name":"Investigating T Cell Immune Dynamics and IL-6's Duality in a Microfluidic Lung Tumor Model.","description":"Interleukin 6 (IL-6), produced by immune cells, is crucial in promoting T cell trafficking to infection and inflammation sites, influencing various physiological and pathological processes. Concentrations of IL-6 and other cytokines and chemokines can influence T cell differentiation and activation. Understanding the dual faces of IL-6 within the tumor microenvironment is crucial to understanding its role. A flow-based microsystem was designed to investigate CD4<sup>+</sup> T cell activation in response to different IL-6 gradients in an under-control 3D culture. The study found that cancer cells' response to varying IL-6 concentrations was dynamic and dose-sensitive, with immune cell migration rates showing sensitivity to the IL-6 gradient. A549 cell expansion increases gradually and time-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-05T00:25:29.895Z","creation":"2025-04-05T00:25:29.895Z"},"accession":"S-EPMC11758792","cross_references":{"pubmed":["39471283"],"doi":["10.1021/acsami.4c09065"]}}