{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Giordano U"],"pubmed_abstract":["<b>Background</b>: The implementation of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) has brought a significant improvement in the prognosis for CML patients and a decrease in the number of patients requiring allogeneic hematopoietic stem cell transplantation (allo-HCT). Nevertheless, the impact of TKIs on allo-HCT outcomes has not been thoroughly explored. <b>Objectives</b>: The main endpoint of our research was to assess the impact of prior TKI treatment on acute graft-versus-host disease (aGvHD) and chronic graft-versus-host disease (cGvHD). <b>Methods</b>: In our retrospective analysis, we included 240 patients treated between 1993 and 2013 and divided them into three groups according to the therapy administered prior to haploidentical, matched-r"],"journal":["Biomedicines"],"pagination":["163"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11759780"],"repository":["biostudies-literature"],"pubmed_title":["Impact of First- and Second-Generation Tyrosine Kinase Inhibitors on the Development of Graft-Versus-Host Disease in Individuals with Chronic Myeloid Leukemia: A Retrospective Analysis on Behalf of the Polish Adult Leukemia Group."],"pmcid":["PMC11759780"],"pubmed_authors":["Dybko Z","Dybko J","Zaucha JM","Kujawska J","Giebel S","Piekarska A","Prejzner W","Dudek K","Giordano U","Gil L"],"additional_accession":[]},"is_claimable":false,"name":"Impact of First- and Second-Generation Tyrosine Kinase Inhibitors on the Development of Graft-Versus-Host Disease in Individuals with Chronic Myeloid Leukemia: A Retrospective Analysis on Behalf of the Polish Adult Leukemia Group.","description":"<b>Background</b>: The implementation of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) has brought a significant improvement in the prognosis for CML patients and a decrease in the number of patients requiring allogeneic hematopoietic stem cell transplantation (allo-HCT). Nevertheless, the impact of TKIs on allo-HCT outcomes has not been thoroughly explored. <b>Objectives</b>: The main endpoint of our research was to assess the impact of prior TKI treatment on acute graft-versus-host disease (aGvHD) and chronic graft-versus-host disease (cGvHD). <b>Methods</b>: In our retrospective analysis, we included 240 patients treated between 1993 and 2013 and divided them into three groups according to the therapy administered prior to haploidentical, matched-r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-19T18:19:43.258Z","creation":"2025-04-19T18:19:43.258Z"},"accession":"S-EPMC11759780","cross_references":{"pubmed":["39857747"],"doi":["10.3390/biomedicines13010163"]}}