{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Qiu G"],"pubmed_abstract":["COVID-19 vaccination is the most effective strategy for preventing severe disease and death. Inactivated vaccines are the most accessible type of COVID-19 vaccines in developing countries. Several studies, including work from our group, have demonstrated that the third dose (booster vaccination) of inactivated COVID-19 vaccine induces robust humoral and cellular immune responses. The present study aimed to examine miRNA expression profile in participants who received a homologous third dose of the CoronaVac vaccine. Samples of peripheral blood mononuclear cells (PBMCs) were collected from healthcare volunteers both before and 1-2 weeks after the booster dose. miRNA microarray analysis in a discovery cohort of six volunteers identified 67 miRNAs with differential expression. Subsequently, t"],"journal":["PeerJ"],"pagination":["e18856"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11760199"],"repository":["biostudies-literature"],"pubmed_title":["Altered expression of miRNA profile in peripheral blood mononuclear cells following the third dose of inactivated COVID-19 vaccine."],"pmcid":["PMC11760199"],"pubmed_authors":["Qian H","Qiu G","Xia J","Shu Q","Le Z","Zang R","Zheng G","Zhang R","Huang R","Wang J","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"Altered expression of miRNA profile in peripheral blood mononuclear cells following the third dose of inactivated COVID-19 vaccine.","description":"COVID-19 vaccination is the most effective strategy for preventing severe disease and death. Inactivated vaccines are the most accessible type of COVID-19 vaccines in developing countries. Several studies, including work from our group, have demonstrated that the third dose (booster vaccination) of inactivated COVID-19 vaccine induces robust humoral and cellular immune responses. The present study aimed to examine miRNA expression profile in participants who received a homologous third dose of the CoronaVac vaccine. Samples of peripheral blood mononuclear cells (PBMCs) were collected from healthcare volunteers both before and 1-2 weeks after the booster dose. miRNA microarray analysis in a discovery cohort of six volunteers identified 67 miRNAs with differential expression. Subsequently, t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T18:06:19.46Z","creation":"2025-04-04T22:07:48.013Z"},"accession":"S-EPMC11760199","cross_references":{"pubmed":["39866557"],"doi":["10.7717/peerj.18856"]}}