biostudies-literatureShen HPing Zhu26https://www.ebi.ac.uk/biostudies/studies/S-EPMC11760873biostudies-literatureUnknown13(1)<b>Objectives:</b> Angiogenic T cells (Tang) are crucial in promoting angiogenesis, with the loss of CD28 serving as a marker for highly differentiated and senescent T cells. This study aims to investigate the characteristics and potential roles of CD8⁺CD28^null Tang in patients with ANCA-associated vasculitis (AAV). <b>Methods:</b> A cohort of AAV patients and matched healthy controls (HCs) were analyzed. Flow cytometry was used to assess the profiles of circulating CD8⁺CD28^null Tang. In vitro functional assays were performed to evaluate the pathogenic properties of CD8⁺CD28^null Tang. <b>Results</b>: CD8⁺CD28^null Tang levels were significantly higher in the peripheral blood of AAV patients compared to HBiomedicinesThe Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis.PMC1176087392169211Zheng ZZhang KChen LLiu RZhang LShen HWang JMiao JZhang PZhu PLi ZSun HZhang BfalseThe Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis.<b>Objectives:</b> Angiogenic T cells (Tang) are crucial in promoting angiogenesis, with the loss of CD28 serving as a marker for highly differentiated and senescent T cells. This study aims to investigate the characteristics and potential roles of CD8⁺CD28^null Tang in patients with ANCA-associated vasculitis (AAV). <b>Methods:</b> A cohort of AAV patients and matched healthy controls (HCs) were analyzed. Flow cytometry was used to assess the profiles of circulating CD8⁺CD28^null Tang. In vitro functional assays were performed to evaluate the pathogenic properties of CD8⁺CD28^null Tang. <b>Results</b>: CD8⁺CD28^null Tang levels were significantly higher in the peripheral blood of AAV patients compared to H2024-01-01T00:00:00Z2024 Dec2026-06-27T03:22:36.251Z2025-04-05T00:25:45.55ZS-EPMC117608733985761110.3390/biomedicines13010026