{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Britton GJ"],"funding":["NIDDK NIH HHS","Versus Arthritis","CSRD VA"],"pubmed_abstract":["We examine disease-specific and cross-disease functions of the human gut microbiome by colonizing germ-free mice, at risk for inflammatory arthritis, colitis, or neuroinflammation, with over 100 human fecal microbiomes from subjects with rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, ulcerative colitis, Crohn's disease, or colorectal cancer. We find common inflammatory phenotypes driven by microbiomes from individuals with intestinal inflammation or inflammatory arthritis, as well as distinct functions specific to microbiomes from multiple sclerosis patients. Inflammatory disease in mice colonized with human microbiomes correlated with systemic inflammation, measured by C-reactive protein, in the human donors. These cross-disease patterns of human microbiome pathogenicit"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.01.14.633015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11761010"],"repository":["biostudies-literature"],"pubmed_title":["Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein."],"pmcid":["PMC11761010"],"funding_grant_id":["R01 DK123749","21226","R01 DK112978","IK2 CX001717","F30 DK131862","R01 DK124133"],"pubmed_authors":["Taylor PC","Braun J","Mogno I","Helmus D","Dubinsky MC","Desch AN","Tankou SK","Bongers G","Colmenero P","Raza K","Lam LH","Littman D","Reyes-Mercedes P","Chen-Liaw A","Huttenhower C","Penkava F","Bullers SJ","Faith JJ","Simmons S","Jacobs JP","Filer A","Bowness P","Plitt T","Gevers D","Britton GJ","Brough I"],"additional_accession":[]},"is_claimable":false,"name":"Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein.","description":"We examine disease-specific and cross-disease functions of the human gut microbiome by colonizing germ-free mice, at risk for inflammatory arthritis, colitis, or neuroinflammation, with over 100 human fecal microbiomes from subjects with rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, ulcerative colitis, Crohn's disease, or colorectal cancer. We find common inflammatory phenotypes driven by microbiomes from individuals with intestinal inflammation or inflammatory arthritis, as well as distinct functions specific to microbiomes from multiple sclerosis patients. Inflammatory disease in mice colonized with human microbiomes correlated with systemic inflammation, measured by C-reactive protein, in the human donors. These cross-disease patterns of human microbiome pathogenicit","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-03T23:23:16.373Z","creation":"2025-04-03T23:23:16.373Z"},"accession":"S-EPMC11761010","cross_references":{"pubmed":["39868147"],"doi":["10.1101/2025.01.14.633015"]}}