{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen KA"],"funding":["Leona M. and Harry B. Helmsley Charitable Trust","NIDDK NIH HHS","NIEHS NIH HHS","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS","NIH HHS"],"pagination":["203-214"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11761463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(1)"],"pubmed_abstract":["<h4>Background</h4>Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by complications such as strictures, fistulas, and neoplasia. Despite medical advancements, a significant number of patients with Crohn's disease require surgery, and many experience post-operative complications and recurrence. Previous studies have analyzed gene expression to study recurrence and post-operative complications independently. This study aims to identify overlapping differentially expressed genes and pathways for recurrence and post-operative complications.<h4>Methods</h4>A dataset including 45 patients with Crohn's disease, including gene expression from ileum and colon tissue, endoscopic recurrence, and intra-abdominal septic complications was anal"],"journal":["Digestive diseases and sciences"],"pubmed_title":["Post-operative Crohn's Disease Recurrence and Infectious Complications: A Transcriptomic Analysis."],"pmcid":["PMC11761463"],"funding_grant_id":["R01 DK136262","P30 CA016086","SHARE Project 2","P30 ES010126","T32 GM135123","P01DK094779","P01 DK094779","T32-CA244125","R01 DK104828"],"pubmed_authors":["Silverstein SR","Schaner MR","Lau GW","Kennedy Ng MM","Bauer MJ","Gomez SM","Sheikh SZ","Furey TS","Chen KA","Zhu LC","Lian G","Gartner V","Darlington KC","Avalos K","Nishiyama NC","Joisa CU","Beasley C","Kapadia MR","Butler L"],"additional_accession":[]},"is_claimable":false,"name":"Post-operative Crohn's Disease Recurrence and Infectious Complications: A Transcriptomic Analysis.","description":"<h4>Background</h4>Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by complications such as strictures, fistulas, and neoplasia. Despite medical advancements, a significant number of patients with Crohn's disease require surgery, and many experience post-operative complications and recurrence. Previous studies have analyzed gene expression to study recurrence and post-operative complications independently. This study aims to identify overlapping differentially expressed genes and pathways for recurrence and post-operative complications.<h4>Methods</h4>A dataset including 45 patients with Crohn's disease, including gene expression from ileum and colon tissue, endoscopic recurrence, and intra-abdominal septic complications was anal","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-21T23:51:18.039Z","creation":"2025-04-05T19:22:23.853Z"},"accession":"S-EPMC11761463","cross_references":{"pubmed":["39215865"],"doi":["10.1007/s10620-024-08595-3"]}}