biostudies-literatureChen KALeona M. and Harry B. Helmsley Charitable TrustNIDDK NIH HHSNIEHS NIH HHSNCI NIH HHSNational Institutes of HealthNIGMS NIH HHSNIH HHS203-214https://www.ebi.ac.uk/biostudies/studies/S-EPMC11761463biostudies-literatureUnknown70(1)<h4>Background</h4>Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by complications such as strictures, fistulas, and neoplasia. Despite medical advancements, a significant number of patients with Crohn's disease require surgery, and many experience post-operative complications and recurrence. Previous studies have analyzed gene expression to study recurrence and post-operative complications independently. This study aims to identify overlapping differentially expressed genes and pathways for recurrence and post-operative complications.<h4>Methods</h4>A dataset including 45 patients with Crohn's disease, including gene expression from ileum and colon tissue, endoscopic recurrence, and intra-abdominal septic complications was analDigestive diseases and sciencesPost-operative Crohn's Disease Recurrence and Infectious Complications: A Transcriptomic Analysis.PMC11761463R01 DK136262P30 CA016086SHARE Project 2P30 ES010126T32 GM135123P01DK094779P01 DK094779T32-CA244125R01 DK104828Silverstein SRSchaner MRLau GWKennedy Ng MMBauer MJGomez SMSheikh SZFurey TSChen KAZhu LCLian GGartner VDarlington KCAvalos KNishiyama NCJoisa CUBeasley CKapadia MRButler LfalsePost-operative Crohn's Disease Recurrence and Infectious Complications: A Transcriptomic Analysis.<h4>Background</h4>Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by complications such as strictures, fistulas, and neoplasia. Despite medical advancements, a significant number of patients with Crohn's disease require surgery, and many experience post-operative complications and recurrence. Previous studies have analyzed gene expression to study recurrence and post-operative complications independently. This study aims to identify overlapping differentially expressed genes and pathways for recurrence and post-operative complications.<h4>Methods</h4>A dataset including 45 patients with Crohn's disease, including gene expression from ileum and colon tissue, endoscopic recurrence, and intra-abdominal septic complications was anal2025-01-01T00:00:00Z2025 Jan2025-04-21T23:51:18.039Z2025-04-05T19:22:23.853ZS-EPMC117614633921586510.1007/s10620-024-08595-3