{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gou J"],"funding":["Young Scholars of Shaanxi Province","the Natural Science Foundation of Shaanxi Province","the National Science Foundation of China","Shaanxi Innovation Team Project"],"pagination":["43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11761745"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Fat mass and obesity-associated protein (FTO) was the first m6A demethylase identified, which is responsible for eliminating m6A modifications in target RNAs. While it is well-established that numerous cytosolic and nuclear proteins undergo O-GlcNAcylation, the possibility of FTO being O-GlcNAcylated and its functional implications remain unclear. This study found that a negative correlation between FTO expression and O-GlcNAcylation in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The decreased O-GlcNAcylation on FTO can result in diminished m6A modification of SRY-related high mobility group box 4 (SOX4). This led to the promotion of cell apoptosis and inhibition of cell proliferation in MDS/AML. The O-GlcNAcylation of FTO stabilized SOX4 transcripts in a"],"journal":["Cell communication and signaling : CCS"],"pubmed_title":["O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation."],"pmcid":["PMC11761745"],"funding_grant_id":["(2021SF-294)","(2023-CX-TD-58)","No. 32071274","(2021JC-39)","No. 82370147"],"pubmed_authors":["Kang E","Li X","Lei L","Tan Z","Feng Y","Guan F","Gao J","Gou J","Bi J","Wang K","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation.","description":"Fat mass and obesity-associated protein (FTO) was the first m6A demethylase identified, which is responsible for eliminating m6A modifications in target RNAs. While it is well-established that numerous cytosolic and nuclear proteins undergo O-GlcNAcylation, the possibility of FTO being O-GlcNAcylated and its functional implications remain unclear. This study found that a negative correlation between FTO expression and O-GlcNAcylation in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The decreased O-GlcNAcylation on FTO can result in diminished m6A modification of SRY-related high mobility group box 4 (SOX4). This led to the promotion of cell apoptosis and inhibition of cell proliferation in MDS/AML. The O-GlcNAcylation of FTO stabilized SOX4 transcripts in a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-18T14:28:01.817Z","creation":"2025-04-07T00:39:34.324Z"},"accession":"S-EPMC11761745","cross_references":{"pubmed":["39849461"],"doi":["10.1186/s12964-025-02058-6"]}}