{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["70(1)"],"submitter":["Oryasin AG"],"pubmed_abstract":["<h4>Purpose</h4>This study aimed to assess the anticoccidial effects of betaine and a vaccine compared to monensin sodium in experimentally induced coccidiosis in broiler chickens.<h4>Methods</h4>600 day-old broiler chickens (Ross 308) were randomly assigned to five groups, each with four replicates of 30 birds. While the control group received a basal diet, two experimental groups received basal diet supplemented with either 100 mg/kg monensin sodium or 2.0 g/kg betaine. The remaining experimental groups received a commercial coccidiosis vaccine alone or in combination with betaine. All chickens were challenged with sporulated field-mixed Eimeria species at 20 days of age.<h4>Results</h4>Throughout the study, vaccinated birds showed superior performance in terms of body weight gain (BWG) and feed conversion ratio (FCR) compared to other anticoccidial treatments (P < 0.05), followed by betaine, vaccine + betaine, and monensin treatments in descending order. While all anticoccidial regimens significantly reduced fecal oocyst output only at the beginning of the observation period, this effect diminished thereafter (P < 0.05). Supplementation with monensin and vaccination against coccidiosis significantly decreased small intestine weight compared to untreated controls (P < 0.01), with a numerical decrease observed in chicks fed betaine-supplemented diets and treated with the combination of betaine and vaccine.<h4>Conclusion</h4>Notably, there has been no prior study comparing betaine with monensin sodium and a coccidiosis vaccine. These findings suggest that dietary betaine supplementation and a commercial coccidiosis vaccine containing mixed Eimeria spp. may offer benefits in controlling coccidiosis, presenting viable, cost-effective, sustainable, and safe alternatives to conventional ionophore anticoccidials, with added benefits of no residue and reduced resistance hazards for both animal and human consumption."],"journal":["Acta parasitologica"],"pagination":["25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11761998"],"repository":["biostudies-literature"],"pubmed_title":["Investigation of Betaine and Vaccine Efficacy for Coccidiosis Prevention in Broilers."],"pmcid":["PMC11761998"],"pubmed_authors":["Eren H","Oryasin AG"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of Betaine and Vaccine Efficacy for Coccidiosis Prevention in Broilers.","description":"<h4>Purpose</h4>This study aimed to assess the anticoccidial effects of betaine and a vaccine compared to monensin sodium in experimentally induced coccidiosis in broiler chickens.<h4>Methods</h4>600 day-old broiler chickens (Ross 308) were randomly assigned to five groups, each with four replicates of 30 birds. While the control group received a basal diet, two experimental groups received basal diet supplemented with either 100 mg/kg monensin sodium or 2.0 g/kg betaine. The remaining experimental groups received a commercial coccidiosis vaccine alone or in combination with betaine. All chickens were challenged with sporulated field-mixed Eimeria species at 20 days of age.<h4>Results</h4>Throughout the study, vaccinated birds showed superior performance in terms of body weight gain (BWG) and feed conversion ratio (FCR) compared to other anticoccidial treatments (P < 0.05), followed by betaine, vaccine + betaine, and monensin treatments in descending order. While all anticoccidial regimens significantly reduced fecal oocyst output only at the beginning of the observation period, this effect diminished thereafter (P < 0.05). Supplementation with monensin and vaccination against coccidiosis significantly decreased small intestine weight compared to untreated controls (P < 0.01), with a numerical decrease observed in chicks fed betaine-supplemented diets and treated with the combination of betaine and vaccine.<h4>Conclusion</h4>Notably, there has been no prior study comparing betaine with monensin sodium and a coccidiosis vaccine. These findings suggest that dietary betaine supplementation and a commercial coccidiosis vaccine containing mixed Eimeria spp. may offer benefits in controlling coccidiosis, presenting viable, cost-effective, sustainable, and safe alternatives to conventional ionophore anticoccidials, with added benefits of no residue and reduced resistance hazards for both animal and human consumption.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-05T11:33:58.961Z","creation":"2025-04-05T11:33:58.961Z"},"accession":"S-EPMC11761998","cross_references":{"pubmed":["39853567"],"doi":["10.1007/s11686-024-00967-z"]}}