biostudies-literatureKuang XScientific Research Fund of Hunan Provincial Education DepartmentNatural Science Foundation of Hunan ProvinceNational Natural Science Foundation of ChinaNational Key Research and Development Program of China57https://www.ebi.ac.uk/biostudies/studies/S-EPMC11762372biostudies-literatureUnknown14(1)Plants frequently encounter relatively low and fluctuating potassium (K⁺) concentrations in soil, with roots serving as primary responders to this stress. Histone modifications, such as de-/acetylation, can function as epigenetic markers of stress-inducible genes. However, the signaling network between histone modifications and low-K⁺ (LK) response pathways remains unclear. This study investigated the regulatory role of Histone Deacetylase Complex 1 (HDC1) in primary root growth of <i>Arabidopsis thaliana</i> under K⁺ deficiency stress. Using a <i>hdc1-2</i> mutant line, we observed that HDC1 positively regulated root growth under LK conditions. Compared to wild-type (WT) plants, the <i>hdc1-2</i> mutant exhibited significantly inhibited primary root growthBiologyHDC1 Promotes Primary Root Elongation by Regulating Auxin and K&lt;sup&gt;+&lt;/sup&gt; Homeostasis in Response to Low-K&lt;sup&gt;+&lt;/sup&gt; Stress.PMC11762372309000992024JJ51962018YFD100040423A0189Huang CWang RHuang ZXiang JZeng JLin WLiu QChen HKuang XSu YfalseHDC1 Promotes Primary Root Elongation by Regulating Auxin and K&lt;sup&gt;+&lt;/sup&gt; Homeostasis in Response to Low-K&lt;sup&gt;+&lt;/sup&gt; Stress.Plants frequently encounter relatively low and fluctuating potassium (K⁺) concentrations in soil, with roots serving as primary responders to this stress. Histone modifications, such as de-/acetylation, can function as epigenetic markers of stress-inducible genes. However, the signaling network between histone modifications and low-K⁺ (LK) response pathways remains unclear. This study investigated the regulatory role of Histone Deacetylase Complex 1 (HDC1) in primary root growth of <i>Arabidopsis thaliana</i> under K⁺ deficiency stress. Using a <i>hdc1-2</i> mutant line, we observed that HDC1 positively regulated root growth under LK conditions. Compared to wild-type (WT) plants, the <i>hdc1-2</i> mutant exhibited significantly inhibited primary root growth2025-01-01T00:00:00Z2025 Jan2025-04-04T11:46:19.661Z2025-04-04T11:46:19.661ZS-EPMC117623723985728810.3390/biology14010057