biostudies-literatureWang Ythe Key Development Project of Science and Technology Bureau in Xuzhou (Social development)the Project supported by Xuzhou Medical Universitythe Key Laboratory of Jiangsu Province Open projectthe Project supported by the Affiliated Hospital of Xuzhou Medical University20https://www.ebi.ac.uk/biostudies/studies/S-EPMC11762886biostudies-literatureUnknown44(1)<h4>Aims</h4>This study aims to assess the serum levels of pepsinogen (PG)I, PG II, and gastrin (G17) in patients with gastric intestinal metaplasia (GIM) and evaluate their correlation with demographic characteristics.<h4>Methods</h4>A total of 247 normal controls (NC) and 240 patients diagnosed with GIM were enrolled in this study. All participants underwent a gastroscopy procedure followed by pathological examination for diagnosis confirmation. The expression level of PGI, PG II, and G 17 was detected by fluorescence immunochromatography and Hp infection was detected by 13-carbon breath test. The demographic characteristics of the subjects were obtained through questionnaires.<h4>Results</h4>Compared to the NC group, the GIM group showed a reduction in PG II expression level [10.71(6.40Journal of health, population, and nutritionHp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study.PMC11762886SJCX24-15432023ZL19KC22233XZSYSKF2021029Cao XLi SFei SWang YChen SPang XShan BfalseHp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study.<h4>Aims</h4>This study aims to assess the serum levels of pepsinogen (PG)I, PG II, and gastrin (G17) in patients with gastric intestinal metaplasia (GIM) and evaluate their correlation with demographic characteristics.<h4>Methods</h4>A total of 247 normal controls (NC) and 240 patients diagnosed with GIM were enrolled in this study. All participants underwent a gastroscopy procedure followed by pathological examination for diagnosis confirmation. The expression level of PGI, PG II, and G 17 was detected by fluorescence immunochromatography and Hp infection was detected by 13-carbon breath test. The demographic characteristics of the subjects were obtained through questionnaires.<h4>Results</h4>Compared to the NC group, the GIM group showed a reduction in PG II expression level [10.71(6.402025-01-01T00:00:00Z2025 Jan2025-04-21T23:50:22.54Z2025-04-05T19:21:58.886ZS-EPMC117628863985676110.1186/s41043-025-00756-y