{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Han J"],"funding":["National Health and Medical Research Council"],"pagination":["108"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11763000"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Background</h4>The increasing prevalence of drug-resistant tuberculosis (TB) underscores the urgent need for novel antimicrobial agents.<h4>Methods</h4>This study integrates cultivation optimization, nuclear magnetic resonance (NMR) fingerprinting, and principal component analysis (PCA) to explore microbial secondary metabolites as potential anti-TB agents.<h4>Results</h4>Using the combined approach, 11 bioactive compounds were isolated and identified, all exhibiting anti-<i>Mycobacterium bovis</i> BCG activity. Notable findings include borrelidin, a potent threonyl-tRNA synthetase inhibitor with broad biological activities, and L-O-Lac-L-Val-D-O-Hiv-D-Val, a peptide isolated for the first time from a plant endophyte, demonstrating broad-spectrum antimicrobial activity. Additionally, e"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes."],"pmcid":["PMC11763000"],"funding_grant_id":["2017517"],"pubmed_authors":["Liu X","Liu M","Quinn RJ","Han J","Zhang L"],"additional_accession":[]},"is_claimable":false,"name":"Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes.","description":"<h4>Background</h4>The increasing prevalence of drug-resistant tuberculosis (TB) underscores the urgent need for novel antimicrobial agents.<h4>Methods</h4>This study integrates cultivation optimization, nuclear magnetic resonance (NMR) fingerprinting, and principal component analysis (PCA) to explore microbial secondary metabolites as potential anti-TB agents.<h4>Results</h4>Using the combined approach, 11 bioactive compounds were isolated and identified, all exhibiting anti-<i>Mycobacterium bovis</i> BCG activity. Notable findings include borrelidin, a potent threonyl-tRNA synthetase inhibitor with broad biological activities, and L-O-Lac-L-Val-D-O-Hiv-D-Val, a peptide isolated for the first time from a plant endophyte, demonstrating broad-spectrum antimicrobial activity. Additionally, e","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T22:06:57.822Z","creation":"2025-04-04T22:06:57.822Z"},"accession":"S-EPMC11763000","cross_references":{"pubmed":["39858393"],"doi":["10.3390/antibiotics14010108"]}}