{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schroeter CA"],"funding":["the Ministry of Science and Higher Education of RF","NARSAD Brain and Behavior Foundation, USA","European Union's Horizon 2020"],"pagination":["67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11764023"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing their function. Little is known about how altered palmitoylation affects function at the systemic level and contributes to CNS pathology. However, recent studies suggested a role for the downregulation of palmitoyl acetyltransferase (DHHC) 21 gene expression in the development of Major Depressive Disorder (MDD)-like syndrome. Here, we sought to investigate how susceptibility (sucrose preference below 65%) or resilience (sucrose preference > 65%) to stress-induced anhedonia affects DHHC gene expression in the hippocampus of C57BL/6J mice during the phase of spontaneous"],"journal":["Biomolecules"],"pubmed_title":["Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility."],"pmcid":["PMC11764023"],"funding_grant_id":["101007642","075-15-2022-310","17611","FGFU-2022-0013"],"pubmed_authors":["Morozov S","Shulgin B","Costa-Nunes JP","Umriukhin A","Strekalova T","Schroeter CA","Gorlova A","Sicker M","Burova A"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility.","description":"Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing their function. Little is known about how altered palmitoylation affects function at the systemic level and contributes to CNS pathology. However, recent studies suggested a role for the downregulation of palmitoyl acetyltransferase (DHHC) 21 gene expression in the development of Major Depressive Disorder (MDD)-like syndrome. Here, we sought to investigate how susceptibility (sucrose preference below 65%) or resilience (sucrose preference > 65%) to stress-induced anhedonia affects DHHC gene expression in the hippocampus of C57BL/6J mice during the phase of spontaneous","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-21T23:56:13.934Z","creation":"2025-04-05T19:21:25.102Z"},"accession":"S-EPMC11764023","cross_references":{"pubmed":["39858460"],"doi":["10.3390/biom15010067"]}}