{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["49(1)"],"submitter":["Kim M"],"pubmed_abstract":["<h4>Background</h4>Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging.<h4>Methods</h4>Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan was examined in <i>Caenorhabditis elegans</i>, with a focus on mitophagy pathways.<h4>Results</h4>GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expre"],"journal":["Journal of ginseng research"],"pagination":["92-102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11764779"],"repository":["biostudies-literature"],"pubmed_title":["Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism."],"pmcid":["PMC11764779"],"pubmed_authors":["Jung SM","Roh JH","Kim J","Kim M","Ryu D","Cho D","Kim SH","Ha KT","Kim WG","Jin EJ","Wei S","Choi YJ","Oh CM","Jo Y"],"additional_accession":[]},"is_claimable":false,"name":"Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism.","description":"<h4>Background</h4>Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging.<h4>Methods</h4>Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan was examined in <i>Caenorhabditis elegans</i>, with a focus on mitophagy pathways.<h4>Results</h4>GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expre","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T17:25:39.258Z","creation":"2025-04-04T13:11:22.949Z"},"accession":"S-EPMC11764779","cross_references":{"pubmed":["39872286"],"doi":["10.1016/j.jgr.2024.11.002"]}}