biostudies-literatureUnknown49(1)Kim M<h4>Background</h4>Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging.<h4>Methods</h4>Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan was examined in <i>Caenorhabditis elegans</i>, with a focus on mitophagy pathways.<h4>Results</h4>GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expreJournal of ginseng research92-102https://www.ebi.ac.uk/biostudies/studies/S-EPMC11764779biostudies-literatureGinsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism.PMC11764779Jung SMRoh JHKim JKim MRyu DCho DKim SHHa KTKim WGJin EJWei SChoi YJOh CMJo YfalseGinsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism.<h4>Background</h4>Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging.<h4>Methods</h4>Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan was examined in <i>Caenorhabditis elegans</i>, with a focus on mitophagy pathways.<h4>Results</h4>GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expre2025-01-01T00:00:00Z2025 Jan2026-06-02T17:25:39.258Z2025-04-04T13:11:22.949ZS-EPMC117647793987228610.1016/j.jgr.2024.11.002