{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang M"],"funding":["the health commission of Zhejiang Province of China","Natural Science Foundation of Zhejiang Province of China","National Natural Science Foundation of China"],"pagination":["31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11765366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background/objectives</h4>UFMylation, a newly identified ubiquitin-like modification, modulates a variety of physiological processes, including endoplasmic reticulum homeostasis maintenance, DNA damage response, embryonic development, and tumor progression. Recent reports showed that UFMylation plays a protective role in preventing liver steatosis and fibrosis, serving as a defender of liver homeostasis in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the regulation of UFMylation in MASLD remains unclear. This study aimed to determine the expressed patterns of UFMylation components in multiple tissues of leptin-deficient <i>ob/ob</i> mice and high-fat diet (HFD)-fed mice, which are mimicking the conditions of MASLD.<h4>Methods</h4>The <i>"],"journal":["Genes"],"pubmed_title":["Systematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease."],"pmcid":["PMC11765366"],"funding_grant_id":["32270751, 82371571","2024KY239","LQ24C070003, LY24H250002"],"pubmed_authors":["Jiang Y","Liu J","Zeng Q","Zhang Z","Zhang J","Chen Y","Jiang M","Zhang C","Wang Y","Qi S","Wang J","Duan Y"],"additional_accession":[]},"is_claimable":false,"name":"Systematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease.","description":"<h4>Background/objectives</h4>UFMylation, a newly identified ubiquitin-like modification, modulates a variety of physiological processes, including endoplasmic reticulum homeostasis maintenance, DNA damage response, embryonic development, and tumor progression. Recent reports showed that UFMylation plays a protective role in preventing liver steatosis and fibrosis, serving as a defender of liver homeostasis in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the regulation of UFMylation in MASLD remains unclear. This study aimed to determine the expressed patterns of UFMylation components in multiple tissues of leptin-deficient <i>ob/ob</i> mice and high-fat diet (HFD)-fed mice, which are mimicking the conditions of MASLD.<h4>Methods</h4>The <i>","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-04-18T03:26:57.931Z","creation":"2025-04-04T22:06:55.276Z"},"accession":"S-EPMC11765366","cross_references":{"pubmed":["39858578"],"doi":["10.3390/genes16010031"]}}