biostudies-literatureJiang Mthe health commission of Zhejiang Province of ChinaNatural Science Foundation of Zhejiang Province of ChinaNational Natural Science Foundation of China31https://www.ebi.ac.uk/biostudies/studies/S-EPMC11765366biostudies-literatureUnknown16(1)<h4>Background/objectives</h4>UFMylation, a newly identified ubiquitin-like modification, modulates a variety of physiological processes, including endoplasmic reticulum homeostasis maintenance, DNA damage response, embryonic development, and tumor progression. Recent reports showed that UFMylation plays a protective role in preventing liver steatosis and fibrosis, serving as a defender of liver homeostasis in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the regulation of UFMylation in MASLD remains unclear. This study aimed to determine the expressed patterns of UFMylation components in multiple tissues of leptin-deficient <i>ob/ob</i> mice and high-fat diet (HFD)-fed mice, which are mimicking the conditions of MASLD.<h4>Methods</h4>The <i>GenesSystematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease.PMC1176536632270751, 823715712024KY239LQ24C070003, LY24H250002Jiang YLiu JZeng QZhang ZZhang JChen YJiang MZhang CWang YQi SWang JDuan YfalseSystematic Analysis of UFMylation Family Genes in Tissues of Mice with Metabolic Dysfunction-Associated Steatotic Liver Disease.<h4>Background/objectives</h4>UFMylation, a newly identified ubiquitin-like modification, modulates a variety of physiological processes, including endoplasmic reticulum homeostasis maintenance, DNA damage response, embryonic development, and tumor progression. Recent reports showed that UFMylation plays a protective role in preventing liver steatosis and fibrosis, serving as a defender of liver homeostasis in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the regulation of UFMylation in MASLD remains unclear. This study aimed to determine the expressed patterns of UFMylation components in multiple tissues of leptin-deficient <i>ob/ob</i> mice and high-fat diet (HFD)-fed mice, which are mimicking the conditions of MASLD.<h4>Methods</h4>The <i>2024-01-01T00:00:00Z2024 Dec2026-04-18T03:26:57.931Z2025-04-04T22:06:55.276ZS-EPMC117653663985857810.3390/genes16010031