{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Culej Bosnjak D"],"funding":["Croatian Science Foundation","The Terry Fox Foundation and Croatian League Against Cancer as well as the Ministry of Science and Education of the Republic of Croatia and by the Scientific Centre of Excellence for Reproductive and Regenerative Medicine (Grant Agreement KK01.1.1.01.0008"],"pagination":["675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11765620"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(2)"],"pubmed_abstract":["The role of the plasminogen activation system is to regulate the activity of the extracellular protease plasmin. It comprises the urokinase plasminogen activator (uPA), a specific extracellular protease which activates plasminogen, its inhibitor PAI1, and the urokinase plasminogen activator receptor, uPAR, which localizes the urokinase activity. The plasminogen activation system is involved in tissue remodeling through extracellular matrix degradation, and therefore participates in numerous physiological and pathological processes, which make it a potential biomarker. To investigate the role of these molecules in the cellular processes, we cloned human uPA, PAI1, and uPAR and overexpressed them in two cell lines, the glioblastoma line A1235 and the transformed human embryonal kidney cells "],"journal":["International journal of molecular sciences"],"pubmed_title":["Urokinase Plasminogen Activation System Modulation in Transformed Cell Lines."],"pmcid":["PMC11765620"],"funding_grant_id":["KK01.1.1.01.0008","IP-2020-02-2431"],"pubmed_authors":["Korac P","Balent T","Matulic M","Culej Bosnjak D","Antica M"],"additional_accession":[]},"is_claimable":false,"name":"Urokinase Plasminogen Activation System Modulation in Transformed Cell Lines.","description":"The role of the plasminogen activation system is to regulate the activity of the extracellular protease plasmin. It comprises the urokinase plasminogen activator (uPA), a specific extracellular protease which activates plasminogen, its inhibitor PAI1, and the urokinase plasminogen activator receptor, uPAR, which localizes the urokinase activity. The plasminogen activation system is involved in tissue remodeling through extracellular matrix degradation, and therefore participates in numerous physiological and pathological processes, which make it a potential biomarker. To investigate the role of these molecules in the cellular processes, we cloned human uPA, PAI1, and uPAR and overexpressed them in two cell lines, the glioblastoma line A1235 and the transformed human embryonal kidney cells ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-19T18:21:58.88Z","creation":"2025-04-19T18:21:58.88Z"},"accession":"S-EPMC11765620","cross_references":{"pubmed":["39859388"],"doi":["10.3390/ijms26020675"]}}