biostudies-literatureBian XChinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science CenterProject of National Key Laboratory for Tropical Crop BreedingNational Key Laboratory for Tropical Crop BreedingHainan Provincial Natural Science Foundation of ChinaNanhai New Star Technology Innovation Talent Platform Project of Hainan ProvinceChinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of the National Tropical Agricultural Science Center798https://www.ebi.ac.uk/biostudies/studies/S-EPMC11765665biostudies-literatureUnknown26(2)The biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), which are essential for sesquiterpenes and triterpenes, respectively, is primarily governed by the mevalonate pathway, wherein <i>farnesyl pyrophosphate synthase</i> (<i>FPS</i>) plays a pivotal role. This study identified eight members of the FPS gene family in <i>Euphorbia hirta</i>, designated <i>EhFPS1</i>-<i>EhFPS8</i>, through bioinformatics analysis, revealing their distribution across several chromosomes and a notable tandem gene cluster. The genes exhibited strong hydrophilic properties and key functional motifs crucial for enzyme activity. An in-depth analysis of the <i>EhFPS</i> genes highlighted their significant involvement in isoprenoid metabolism and lipid biosynthesis, with expression pInternational journal of molecular sciencesGenome-Wide Identification and Expression Profile of <i>Farnesyl Pyrophosphate Synthase</i> (<i>FPS</i>) Gene Family in <i>Euphorbia Hirta</i> L.PMC11765665NKLTCBCXTD01NHXXRCXM202330324QN304CATASCXTD202401Han QQiang RXu DWang HRehman FDeng ZAn ZBian XWu TWang XWu WCheng HYuan YfalseGenome-Wide Identification and Expression Profile of <i>Farnesyl Pyrophosphate Synthase</i> (<i>FPS</i>) Gene Family in <i>Euphorbia Hirta</i> L.The biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), which are essential for sesquiterpenes and triterpenes, respectively, is primarily governed by the mevalonate pathway, wherein <i>farnesyl pyrophosphate synthase</i> (<i>FPS</i>) plays a pivotal role. This study identified eight members of the FPS gene family in <i>Euphorbia hirta</i>, designated <i>EhFPS1</i>-<i>EhFPS8</i>, through bioinformatics analysis, revealing their distribution across several chromosomes and a notable tandem gene cluster. The genes exhibited strong hydrophilic properties and key functional motifs crucial for enzyme activity. An in-depth analysis of the <i>EhFPS</i> genes highlighted their significant involvement in isoprenoid metabolism and lipid biosynthesis, with expression p2025-01-01T00:00:00Z2025 Jan2026-04-18T03:21:11.899Z2025-04-19T18:23:59.923ZS-EPMC117656653985951810.3390/ijms26020798