{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Olsen SSH"],"funding":["NCCIH NIH HHS","Science Foundation Ireland","NIAID NIH HHS","NIH HHS"],"pagination":["44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11767152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral <i>Anthothela grandiflora,</i> we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F-Q. The metabolites were isolated using both bioassay- and <sup>1</sup>H NMR-guided approaches. One-/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations"],"journal":["Marine drugs"],"pubmed_title":["Anthoteibinenes F-Q: New Sesquiterpenes from the Irish Deep-Sea Coral &lt;i&gt;Anthothela grandiflora&lt;/i&gt;."],"pmcid":["PMC11767152"],"funding_grant_id":["R56 AI154922","1R56AI154922-23A1","SFI/15/1A/3100","R21 AT010939","1R21AT010939-23A1"],"pubmed_authors":["Young RM","Johnson M","Olsen SSH","Cruz Rosa E","Baker BJ","Allcock AL","Afoullouss S"],"additional_accession":[]},"is_claimable":false,"name":"Anthoteibinenes F-Q: New Sesquiterpenes from the Irish Deep-Sea Coral &lt;i&gt;Anthothela grandiflora&lt;/i&gt;.","description":"New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral <i>Anthothela grandiflora,</i> we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F-Q. The metabolites were isolated using both bioassay- and <sup>1</sup>H NMR-guided approaches. One-/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-03T23:23:17.127Z","creation":"2025-04-03T23:23:17.127Z"},"accession":"S-EPMC11767152","cross_references":{"pubmed":["39852546"],"doi":["10.3390/md23010044"]}}