{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chai YX"],"funding":["Shandong Provincial Natural Science Foundation","Foundation of International Innovation Center for Forest Chemicals and Materials Nanjing Forestry University","Yantai \"Double Hundred Plan\""],"pagination":["381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11767409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(2)"],"pubmed_abstract":["A Cu-promoted highly chemoselective dimerization of 5-aminopyrazoles to produce pyrazole-fused pyridazines and pyrazines is reported. The protocol generates switchable products via the direct coupling of C-H/N-H, C-H/C-H and N-H/N-H bonds, with the merits of broad substrate scope and high functional group compatibility. Gram-scale experiments demonstrated the potential applications of this reaction. Moreover, the preliminary fluorescence results uncovered that dipyrazole-fused pyridazines and pyrazines may have some potential applications in materials chemistry."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds."],"pmcid":["PMC11767409"],"funding_grant_id":["ZR2024MB054","No","no"],"pubmed_authors":["Yang X","Zhang QQ","Zhang XH","Sun YY","Chai YX","Zhu YP","Bai YC","Wu AX","Zhao YZ","Li YM","Ren JJ","Zhang XS"],"additional_accession":[]},"is_claimable":false,"name":"5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds.","description":"A Cu-promoted highly chemoselective dimerization of 5-aminopyrazoles to produce pyrazole-fused pyridazines and pyrazines is reported. The protocol generates switchable products via the direct coupling of C-H/N-H, C-H/C-H and N-H/N-H bonds, with the merits of broad substrate scope and high functional group compatibility. Gram-scale experiments demonstrated the potential applications of this reaction. Moreover, the preliminary fluorescence results uncovered that dipyrazole-fused pyridazines and pyrazines may have some potential applications in materials chemistry.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-05T09:32:40.182Z","creation":"2025-04-05T09:32:40.182Z"},"accession":"S-EPMC11767409","cross_references":{"pubmed":["39860249"],"doi":["10.3390/molecules30020381"]}}