biostudies-literatureChai YXShandong Provincial Natural Science FoundationFoundation of International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityYantai "Double Hundred Plan"381https://www.ebi.ac.uk/biostudies/studies/S-EPMC11767409biostudies-literatureUnknown30(2)A Cu-promoted highly chemoselective dimerization of 5-aminopyrazoles to produce pyrazole-fused pyridazines and pyrazines is reported. The protocol generates switchable products via the direct coupling of C-H/N-H, C-H/C-H and N-H/N-H bonds, with the merits of broad substrate scope and high functional group compatibility. Gram-scale experiments demonstrated the potential applications of this reaction. Moreover, the preliminary fluorescence results uncovered that dipyrazole-fused pyridazines and pyrazines may have some potential applications in materials chemistry.Molecules (Basel, Switzerland)5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds.PMC11767409ZR2024MB054NonoYang XZhang QQZhang XHSun YYChai YXZhu YPBai YCWu AXZhao YZLi YMRen JJZhang XSfalse5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds.A Cu-promoted highly chemoselective dimerization of 5-aminopyrazoles to produce pyrazole-fused pyridazines and pyrazines is reported. The protocol generates switchable products via the direct coupling of C-H/N-H, C-H/C-H and N-H/N-H bonds, with the merits of broad substrate scope and high functional group compatibility. Gram-scale experiments demonstrated the potential applications of this reaction. Moreover, the preliminary fluorescence results uncovered that dipyrazole-fused pyridazines and pyrazines may have some potential applications in materials chemistry.2025-01-01T00:00:00Z2025 Jan2025-04-05T09:32:40.182Z2025-04-05T09:32:40.182ZS-EPMC117674093986024910.3390/molecules30020381