biostudies-literatureSong WMajor Science and Technology Project of XinjiangResearch Project of Science and Technology Innovation Talent of XPCC225https://www.ebi.ac.uk/biostudies/studies/S-EPMC11767424biostudies-literatureUnknown17(2)<h4>Objectives</h4>Polysaccharides from <i>Glycyrrhiza</i> are known to have several bioactive effects. Previous studies have found that low-molecular-weight <i>Glycyrrhiza</i> polysaccharide (GP1) is degraded by <i>Muribaculum_sp_H5</i> and promotes the production of beneficial bacteria and metabolites, which improves immune disorder and intestinal injury, and then enhances the body's immune regulation ability. However, the immune regulation effect of GP1 on a healthy body has not been studied. In this study, we aimed to reveal the immune enhancement effect and mechanism of GP1 on healthy mice.<h4>Methods</h4>The cytotoxicity and immunomodulatory activity of GP1 were analyzed by cell experiment; the effects of GP1 on antioxidation, immune regulation and gut microbiota structure of healthyNutrients<i>Glycyrrhiza uralensis</i> Polysaccharide Modulates Characteristic Bacteria and Metabolites, Improving the Immune Function of Healthy Mice.PMC117674242023B02022-32024DB052Zhang GZhang TXue SZhang YWang YSong Wfalse<i>Glycyrrhiza uralensis</i> Polysaccharide Modulates Characteristic Bacteria and Metabolites, Improving the Immune Function of Healthy Mice.<h4>Objectives</h4>Polysaccharides from <i>Glycyrrhiza</i> are known to have several bioactive effects. Previous studies have found that low-molecular-weight <i>Glycyrrhiza</i> polysaccharide (GP1) is degraded by <i>Muribaculum_sp_H5</i> and promotes the production of beneficial bacteria and metabolites, which improves immune disorder and intestinal injury, and then enhances the body's immune regulation ability. However, the immune regulation effect of GP1 on a healthy body has not been studied. In this study, we aimed to reveal the immune enhancement effect and mechanism of GP1 on healthy mice.<h4>Methods</h4>The cytotoxicity and immunomodulatory activity of GP1 were analyzed by cell experiment; the effects of GP1 on antioxidation, immune regulation and gut microbiota structure of healthy2025-01-01T00:00:00Z2025 Jan2025-04-18T16:49:59.51Z2025-04-07T04:18:15.647ZS-EPMC117674243986135510.3390/nu17020225