biostudies-literatureTraversa DELIXIRNextGenIT137https://www.ebi.ac.uk/biostudies/studies/S-EPMC11767486biostudies-literatureUnknown13(1)Polyhydroxybutyrate (PHB) is a biodegradable natural polymer produced by different prokaryotes as a valuable carbon and energy storage compound. Its biosynthesis pathway requires the sole expression of the <i>phaCAB</i> operon, although auxiliary genes play a role in controlling polymer accumulation, degradation, granule formation and stabilization. Due to its biodegradability, PHB is currently regarded as a promising alternative to synthetic plastics for industrial/biotechnological applications. <i>Azohydromonas lata</i> strain H1 has been reported to accumulate PHB by using simple, inexpensive carbon sources. Here, we present the first de novo genome assembly of the <i>A. lata</i> strain H1. The genome assembly is over 7.7 Mb in size, including a circular megaplasmid of approximately 456MicroorganismsDe Novo Assembly of the Polyhydroxybutyrate (PHB) Producer <i>Azohydromonas lata</i> Strain H1 Genome and Genomic Analysis of PHB Production Machinery.PMC11767486IR0000010Calia CPazzani CTraversa DChimienti GManzari CPesole GD'Addabbo POliva MMandorino CChiara MMarzella ATrisolini LScrascia MfalseDe Novo Assembly of the Polyhydroxybutyrate (PHB) Producer <i>Azohydromonas lata</i> Strain H1 Genome and Genomic Analysis of PHB Production Machinery.Polyhydroxybutyrate (PHB) is a biodegradable natural polymer produced by different prokaryotes as a valuable carbon and energy storage compound. Its biosynthesis pathway requires the sole expression of the <i>phaCAB</i> operon, although auxiliary genes play a role in controlling polymer accumulation, degradation, granule formation and stabilization. Due to its biodegradability, PHB is currently regarded as a promising alternative to synthetic plastics for industrial/biotechnological applications. <i>Azohydromonas lata</i> strain H1 has been reported to accumulate PHB by using simple, inexpensive carbon sources. Here, we present the first de novo genome assembly of the <i>A. lata</i> strain H1. The genome assembly is over 7.7 Mb in size, including a circular megaplasmid of approximately 4562025-01-01T00:00:00Z2025 Jan2026-05-23T03:21:49.333Z2025-04-04T20:56:53.957ZS-EPMC117674863985890510.3390/microorganisms13010137