{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Yang HS"],"pubmed_abstract":["<b>Background/Objectives</b>: The currently established equations for calculating low-density lipoprotein cholesterol (LDLc) do not reflect the sex-specific differences in lipid metabolism. We aimed to develop a sex-specific LDLc equation (SSLE) and validate it with three established equations (Friedewald, Sampson-NIH, and ext-Martin-Hopkins) against direct LDLc measurement in Korean adults. <b>Methods:</b> This study included 23,757 subjects (51% male; median age, 51 years) from the 2009-2022 Korean National Health and Nutrition Examination Survey. We developed the SSLE through multiple linear regression incorporating total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), triglycerides (TG), and sex. The validation metrics included Bland-Altman analysis for mean absolute per"],"journal":["Metabolites"],"pagination":["18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11767536"],"repository":["biostudies-literature"],"pubmed_title":["The Validation of a Novel, Sex-Specific LDL-Cholesterol Equation and the Friedewald, Sampson-NIH, and Extended-Martin-Hopkins Equations Against Direct Measurement in Korean Adults."],"pmcid":["PMC11767536"],"pubmed_authors":["Lee S","Yang HS","Kim SN","Hur M"],"additional_accession":[]},"is_claimable":false,"name":"The Validation of a Novel, Sex-Specific LDL-Cholesterol Equation and the Friedewald, Sampson-NIH, and Extended-Martin-Hopkins Equations Against Direct Measurement in Korean Adults.","description":"<b>Background/Objectives</b>: The currently established equations for calculating low-density lipoprotein cholesterol (LDLc) do not reflect the sex-specific differences in lipid metabolism. We aimed to develop a sex-specific LDLc equation (SSLE) and validate it with three established equations (Friedewald, Sampson-NIH, and ext-Martin-Hopkins) against direct LDLc measurement in Korean adults. <b>Methods:</b> This study included 23,757 subjects (51% male; median age, 51 years) from the 2009-2022 Korean National Health and Nutrition Examination Survey. We developed the SSLE through multiple linear regression incorporating total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), triglycerides (TG), and sex. The validation metrics included Bland-Altman analysis for mean absolute per","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-25T18:51:53.072Z","creation":"2025-04-06T07:45:14.949Z"},"accession":"S-EPMC11767536","cross_references":{"pubmed":["39852361"],"doi":["10.3390/metabo15010018"]}}