biostudies-literatureUnknown15(1)Yang HS<b>Background/Objectives</b>: The currently established equations for calculating low-density lipoprotein cholesterol (LDLc) do not reflect the sex-specific differences in lipid metabolism. We aimed to develop a sex-specific LDLc equation (SSLE) and validate it with three established equations (Friedewald, Sampson-NIH, and ext-Martin-Hopkins) against direct LDLc measurement in Korean adults. <b>Methods:</b> This study included 23,757 subjects (51% male; median age, 51 years) from the 2009-2022 Korean National Health and Nutrition Examination Survey. We developed the SSLE through multiple linear regression incorporating total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), triglycerides (TG), and sex. The validation metrics included Bland-Altman analysis for mean absolute perMetabolites18https://www.ebi.ac.uk/biostudies/studies/S-EPMC11767536biostudies-literatureThe Validation of a Novel, Sex-Specific LDL-Cholesterol Equation and the Friedewald, Sampson-NIH, and Extended-Martin-Hopkins Equations Against Direct Measurement in Korean Adults.PMC11767536Lee SYang HSKim SNHur MfalseThe Validation of a Novel, Sex-Specific LDL-Cholesterol Equation and the Friedewald, Sampson-NIH, and Extended-Martin-Hopkins Equations Against Direct Measurement in Korean Adults.<b>Background/Objectives</b>: The currently established equations for calculating low-density lipoprotein cholesterol (LDLc) do not reflect the sex-specific differences in lipid metabolism. We aimed to develop a sex-specific LDLc equation (SSLE) and validate it with three established equations (Friedewald, Sampson-NIH, and ext-Martin-Hopkins) against direct LDLc measurement in Korean adults. <b>Methods:</b> This study included 23,757 subjects (51% male; median age, 51 years) from the 2009-2022 Korean National Health and Nutrition Examination Survey. We developed the SSLE through multiple linear regression incorporating total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), triglycerides (TG), and sex. The validation metrics included Bland-Altman analysis for mean absolute per2025-01-01T00:00:00Z2025 Jan2025-04-25T18:51:53.072Z2025-04-06T07:45:14.949ZS-EPMC117675363985236110.3390/metabo15010018