biostudies-literatureDiaz-Ruiz RBrain & Behavior Research FoundationInstituto de Salud Carlos IIIMinisterio de Ciencia, Innovación y UniversidadesFundacion Familia AlonsoComunidad de Madrid226https://www.ebi.ac.uk/biostudies/studies/S-EPMC11768058biostudies-literatureUnknown17(2)<b>Background/Objectives:</b> Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic pathogenic role. Extraskeletal functions of vitamin D include immunomodulation, and its deficiency has been implicated in immune dysfunction and different forms of cognitive impairment. The aim was to assess changes in cognitive function and inflammation in decompensated patients with cirrhosis receiving vitamin D supplementation. <b>Methods</b>: Patients with cirrhosis discharged from decompensation in two tertiary hospitals in Spain (from September 2017 to January 2020) were assessed beforeNutrientsVitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis.PMC11768058RYC-2017-23144NARSAD 24628ICI20/00063 y PI21/00189PI21/00701M PI24/01298JR14/00019S2022/BMD-7216 AGES 3-CMPI16/00920FI19/00120CNS2023-144038FFA-2024Banares RLopez-Esteban RRapado-Castro MBreton IPoca MCuyas BSoriano GGarcia-Martinez RBlazquez EMorales ADiaz-Ruiz RPanadero-Gomez RFernandez-Castillo MRoman ECorrea-Rocha RBanares IPuerto MfalseVitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis.<b>Background/Objectives:</b> Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic pathogenic role. Extraskeletal functions of vitamin D include immunomodulation, and its deficiency has been implicated in immune dysfunction and different forms of cognitive impairment. The aim was to assess changes in cognitive function and inflammation in decompensated patients with cirrhosis receiving vitamin D supplementation. <b>Methods</b>: Patients with cirrhosis discharged from decompensation in two tertiary hospitals in Spain (from September 2017 to January 2020) were assessed before2025-01-01T00:00:00Z2025 Jan2025-04-04T22:25:00.496Z2025-04-04T22:25:00.496ZS-EPMC117680583986135610.3390/nu17020226