{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Livingstone M"],"funding":["Rural and Environment Science and Analytical Services","Scottish Government Rural","Analytical Services","Environment Science"],"pagination":["89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11768554"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background/objective</h4><i>Chlamydia abortus</i>, the cause of ovine enzootic abortion, is a zoonotic bacterial pathogen and one of the most infectious causes of foetal death in sheep worldwide. Although the disease can be controlled using commercial inactivated and live whole-organism vaccines, there are issues with both, particularly concerning efficacy and safety. Recently, we have described the development of a new COMC (chlamydial outer membrane complex) vaccine based on a detergent-extracted outer membrane protein preparation of the pathogen, which can be delivered in a single inoculation and is both efficacious and safe.<h4>Methods</h4>In this study, we have evaluated the COMC vaccine further in a dose-response titration of the chlamydial antigen content of the vaccine (from 20"],"journal":["Vaccines"],"pubmed_title":["Protective Efficacy of Decreasing Antigen Doses of a <i>Chlamydia abortus</i> Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model."],"pmcid":["PMC11768554"],"funding_grant_id":["not applicable"],"pubmed_authors":["Aitchison K","Palarea-Albaladejo J","Paladino A","Livingstone M","Chianini F","Ciampi F","Longbottom D","Entrican G","Underwood C","Wattegedera SR"],"additional_accession":[]},"is_claimable":false,"name":"Protective Efficacy of Decreasing Antigen Doses of a <i>Chlamydia abortus</i> Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model.","description":"<h4>Background/objective</h4><i>Chlamydia abortus</i>, the cause of ovine enzootic abortion, is a zoonotic bacterial pathogen and one of the most infectious causes of foetal death in sheep worldwide. Although the disease can be controlled using commercial inactivated and live whole-organism vaccines, there are issues with both, particularly concerning efficacy and safety. Recently, we have described the development of a new COMC (chlamydial outer membrane complex) vaccine based on a detergent-extracted outer membrane protein preparation of the pathogen, which can be delivered in a single inoculation and is both efficacious and safe.<h4>Methods</h4>In this study, we have evaluated the COMC vaccine further in a dose-response titration of the chlamydial antigen content of the vaccine (from 20","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-04-08T19:49:01.505Z","creation":"2025-04-06T07:45:54.24Z"},"accession":"S-EPMC11768554","cross_references":{"pubmed":["39852869"],"doi":["10.3390/vaccines13010089"]}}