biostudies-literatureGuevara MFondo Nacional de Innovación y Desarrollo Científico y Tecnológico (FONDOCYT)Brazilian National Research Council (CNPq)Instituto de Salud Carlos III (ISCIII) and European Union NextGeneration EU/Plan de Recuperación, Transformación y ResilienciaAEXCID-Junta de Extremadura8https://www.ebi.ac.uk/biostudies/studies/S-EPMC11768636biostudies-literatureUnknown17(1)<b>Background/Objectives:</b> Genetic polymorphism of the dihydropyrimidine dehydrogenase gene (<i>DPYD</i>) is responsible for the variability found in the metabolism of fluoropyrimidines such as 5-fluorouracil (5-FU), capecitabine, or tegafur. The <i>DPYD</i> genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10-40% of patients treated with fluoropyrimidines develop severe toxicity. The interethnic variability of <i>DPYD</i> gene variants in Afro-Latin Americans is poorly studied, thereby establishing a barrier to the implementation of personalized medicine in these populations. Therefore, the present study aims to analyze the frequency of <i>DPYD</i> variants with clinical relevance in the Dominican population and their association with gPharmaceuticsThe Frequency of <i>DPYD</i> c.557A>G in the Dominican Population and Its Association with African Ancestry.PMC1176863624IA001312807/2022-8 and 200824/2024-4PMP22/00099; BIOFRAM222020-201-2C5-204Penas-Lledo ERodrigues-Soares FLLerena AManochio CDorado Pde la Cruz CGRodriguez EGuevara MfalseThe Frequency of <i>DPYD</i> c.557A>G in the Dominican Population and Its Association with African Ancestry.<b>Background/Objectives:</b> Genetic polymorphism of the dihydropyrimidine dehydrogenase gene (<i>DPYD</i>) is responsible for the variability found in the metabolism of fluoropyrimidines such as 5-fluorouracil (5-FU), capecitabine, or tegafur. The <i>DPYD</i> genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10-40% of patients treated with fluoropyrimidines develop severe toxicity. The interethnic variability of <i>DPYD</i> gene variants in Afro-Latin Americans is poorly studied, thereby establishing a barrier to the implementation of personalized medicine in these populations. Therefore, the present study aims to analyze the frequency of <i>DPYD</i> variants with clinical relevance in the Dominican population and their association with g2024-01-01T00:00:00Z2024 Dec2026-04-22T03:25:57.23Z2025-04-06T07:44:09.03ZS-EPMC117686363986166010.3390/pharmaceutics17010008