biostudies-literatureUnknown54(3)Smayra KThe University of Queensland<h4>Objective</h4>To assess the yield and clinical impact of image-guided bone biopsy for osteomyelitis of the appendicular skeleton.<h4>Materials and methods</h4>A literature search of several databases was conducted from inception to August 2023. Eligible studies reported patients who underwent image-guided bone biopsy for investigation of osteomyelitis of the appendicular skeleton. The pooled proportions were analyzed using a random-effects model. This review was registered in PROSPERO (CRD42023466419).<h4>Results</h4>From 370 initial studies screened, eight met the eligibility criteria, with a total of 700 patients. The pooled technical success rate was 99.6% (95% CI: 0.992, 1.001; I² = 0%). Positive bone cultures were pooled at 31.9% (95% CI: 0.222, 0.416; I² = 87.83%) and negative cultures at 68.1% (95% CI: 0.584, 0.778; I² = 87.83%). Methicillin-Sensitive Staphylococcus Aureus and Methicillin-Resistant Staphylococcus Aureus yield was 24.5% (95% CI: 0.096, 0.394; I² = 90.98%) and 7.6% (95% CI: 0.031, 0.121; I² = 34.42%) respectively. Group A Streptococcus yield was 7.0% (95% CI: 0.014, 0.127; I² = 70.94%). Polymicrobial culture yield was 15.7% (95% CI: 0.018, 0.297; I² = 88.90%). Post-procedural management change rate was 36.5% (95% CI: 0.225, 0.504; I² = 92.39%). No complications were reported across studies.<h4>Conclusion</h4>For patients under investigation of osteomyelitis of the appendicular skeleton, image-guided bone biopsy demonstrates a good rate of technical success. Additional studies may provide further support for the use of image-guided bone biopsy in this population. Image-guided bone biopsy results lead to change in antibiotics therapy in a portion of patients with suspected osteomyelitis suggesting its potential utility in select patients.Skeletal radiology481-492https://www.ebi.ac.uk/biostudies/studies/S-EPMC11769862biostudies-literatureYield and clinical impact of image-guided bone biopsy in osteomyelitis of the appendicular skeleton: a systematic review and meta-analysis.PMC11769862Yap NQEBall JSmayra KThan CAKhoo MWitkowiak MMNakanishi HMiangul SPersson LKMLugard EEAdra MfalseYield and clinical impact of image-guided bone biopsy in osteomyelitis of the appendicular skeleton: a systematic review and meta-analysis.<h4>Objective</h4>To assess the yield and clinical impact of image-guided bone biopsy for osteomyelitis of the appendicular skeleton.<h4>Materials and methods</h4>A literature search of several databases was conducted from inception to August 2023. Eligible studies reported patients who underwent image-guided bone biopsy for investigation of osteomyelitis of the appendicular skeleton. The pooled proportions were analyzed using a random-effects model. This review was registered in PROSPERO (CRD42023466419).<h4>Results</h4>From 370 initial studies screened, eight met the eligibility criteria, with a total of 700 patients. The pooled technical success rate was 99.6% (95% CI: 0.992, 1.001; I² = 0%). Positive bone cultures were pooled at 31.9% (95% CI: 0.222, 0.416; I² = 87.83%) and negative cultures at 68.1% (95% CI: 0.584, 0.778; I² = 87.83%). Methicillin-Sensitive Staphylococcus Aureus and Methicillin-Resistant Staphylococcus Aureus yield was 24.5% (95% CI: 0.096, 0.394; I² = 90.98%) and 7.6% (95% CI: 0.031, 0.121; I² = 34.42%) respectively. Group A Streptococcus yield was 7.0% (95% CI: 0.014, 0.127; I² = 70.94%). Polymicrobial culture yield was 15.7% (95% CI: 0.018, 0.297; I² = 88.90%). Post-procedural management change rate was 36.5% (95% CI: 0.225, 0.504; I² = 92.39%). No complications were reported across studies.<h4>Conclusion</h4>For patients under investigation of osteomyelitis of the appendicular skeleton, image-guided bone biopsy demonstrates a good rate of technical success. Additional studies may provide further support for the use of image-guided bone biopsy in this population. Image-guided bone biopsy results lead to change in antibiotics therapy in a portion of patients with suspected osteomyelitis suggesting its potential utility in select patients.2025-01-01T00:00:00Z2025 Mar2025-04-04T20:56:24.39Z2025-04-04T20:56:24.39ZS-EPMC117698623908002910.1007/s00256-024-04764-7