biostudies-literatureUnknownPyle MNational Institute for Health Research (NIHR)<h4>Background</h4>Stigma of mental health conditions hinders recovery and well-being. The Honest, Open, Proud (HOP) program shows promise in reducing stigma but there is uncertainty about the feasibility of a randomized trial to evaluate a peer-delivered, individual adaptation of HOP for psychosis (Let's Talk).<h4>Methods</h4>A multi-site, Prospective Randomized Open Blinded Evaluation (PROBE) design, feasibility randomised controlled trial (RCT) comparing the peer-delivered intervention (Let's Talk) to treatment as usual (TAU). Follow-up was 2.5 and 6 months. Randomization was via a web-based system, with permuted blocks of random size. Up to 10 sessions of the intervention over 10 weeks were offered. The primary outcome was feasibility data (recruitment, retention, intervention attendanPsychological medicine1-12https://www.ebi.ac.uk/biostudies/studies/S-EPMC11769902biostudies-literatureA feasibility randomized controlled trial of an individually delivered, peer support intervention to reduce the impact of psychosis stigma and discrimination for people with psychosis: the let's talk study.PMC11769902NIHR200460Jones EHazzard RMacLennan GSwingler JMurphy EByrne RDunbar EPyle MPeters SLarson JELet's Talk Research GroupMacafee GPilling SJones WKelly KWood LCorrigan PWHudson JMorrison APfalseA feasibility randomized controlled trial of an individually delivered, peer support intervention to reduce the impact of psychosis stigma and discrimination for people with psychosis: the let's talk study.<h4>Background</h4>Stigma of mental health conditions hinders recovery and well-being. The Honest, Open, Proud (HOP) program shows promise in reducing stigma but there is uncertainty about the feasibility of a randomized trial to evaluate a peer-delivered, individual adaptation of HOP for psychosis (Let's Talk).<h4>Methods</h4>A multi-site, Prospective Randomized Open Blinded Evaluation (PROBE) design, feasibility randomised controlled trial (RCT) comparing the peer-delivered intervention (Let's Talk) to treatment as usual (TAU). Follow-up was 2.5 and 6 months. Randomization was via a web-based system, with permuted blocks of random size. Up to 10 sessions of the intervention over 10 weeks were offered. The primary outcome was feasibility data (recruitment, retention, intervention attendan2024-01-01T00:00:00Z2024 Dec2025-04-04T23:11:27.796Z2025-04-04T23:11:27.796ZS-EPMC117699023972617610.1017/S0033291724002605