{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Sasa N"],"pubmed_abstract":["Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head and neck squamous cell carcinoma (HPV<sup>+</sup> HNSCC). Whole-genome sequencing of 51 tumors revealed intratumor heterogeneity of HPV integration, with 44% of breakpoints subclonal, and a biased distribution of integration breakpoints across the HPV genome. Four HPV physical states were identified, with at least 49% of tumors progressing without integration. HPV integration was associated with APOBEC-induced broad genomic instability and focal genomic instability, including structural variants at integration sites. HPV<sup>+</sup> HNSCCs exhibited almost no smoking-induced mutational signatures. Heterozygous loss of ataxia-telangiectasia mutated (ATM) was observed in 67% of tumors, with its downregula"],"journal":["Nature communications"],"pagination":["1052"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11770129"],"repository":["biostudies-literature"],"pubmed_title":["Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer."],"pmcid":["PMC11770129"],"pubmed_authors":["Kishikawa T","Tanaka H","Sasa N","Suzuki M","Eguchi H","Inohara H","Ito R","Nimura K","Mizoro Y","Mori M","Takenaka Y","Okada Y","Fukusumi T"],"additional_accession":[]},"is_claimable":false,"name":"Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer.","description":"Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head and neck squamous cell carcinoma (HPV<sup>+</sup> HNSCC). Whole-genome sequencing of 51 tumors revealed intratumor heterogeneity of HPV integration, with 44% of breakpoints subclonal, and a biased distribution of integration breakpoints across the HPV genome. Four HPV physical states were identified, with at least 49% of tumors progressing without integration. HPV integration was associated with APOBEC-induced broad genomic instability and focal genomic instability, including structural variants at integration sites. HPV<sup>+</sup> HNSCCs exhibited almost no smoking-induced mutational signatures. Heterozygous loss of ataxia-telangiectasia mutated (ATM) was observed in 67% of tumors, with its downregula","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T23:12:08.353Z","creation":"2025-04-04T23:12:08.353Z"},"accession":"S-EPMC11770129","cross_references":{"pubmed":["39865078"],"doi":["10.1038/s41467-025-56150-z"]}}