biostudies-literatureUnknown57(1)Leng Y<h4>Objective</h4>Whereas a few studies have evaluated vestibular involvement in Fabry disease (FD), the relationship between vestibular/oculomotor abnormalities and disease-specific biomarkers remain unclear. Therefore, we seek to evaluate these quantitatively and analyze their relationship with disease phenotype and biomarkers in FD.<h4>Methods</h4>This cohort study enrolled 37 Chinese FD patients registered in our center. The vestibular/oculomotor examinations were performed, including the videonystagmography, the caloric test and the video head-impulse test. Statistical analyses were made between different subgroups of patients.<h4>Results</h4>Visuo-oculomotor dysfunctions were found in 30/37 (81.1%) patients. Vestibulo-oculomotor dysfunctions were revealed in 9/22 (40.9%) patients. StAnnals of medicine2453626https://www.ebi.ac.uk/biostudies/studies/S-EPMC11770862biostudies-literatureThe vestibular and oculomotor dysfunction in Fabry disease: a cohort study in China.PMC11770862Zhang WLing XLeng YZhao GWang XZhou HZhao YfalseThe vestibular and oculomotor dysfunction in Fabry disease: a cohort study in China.<h4>Objective</h4>Whereas a few studies have evaluated vestibular involvement in Fabry disease (FD), the relationship between vestibular/oculomotor abnormalities and disease-specific biomarkers remain unclear. Therefore, we seek to evaluate these quantitatively and analyze their relationship with disease phenotype and biomarkers in FD.<h4>Methods</h4>This cohort study enrolled 37 Chinese FD patients registered in our center. The vestibular/oculomotor examinations were performed, including the videonystagmography, the caloric test and the video head-impulse test. Statistical analyses were made between different subgroups of patients.<h4>Results</h4>Visuo-oculomotor dysfunctions were found in 30/37 (81.1%) patients. Vestibulo-oculomotor dysfunctions were revealed in 9/22 (40.9%) patients. St2025-01-01T00:00:00Z2025 Dec2025-04-03T23:26:35.427Z2025-04-03T23:26:35.427ZS-EPMC117708623986213310.1080/07853890.2025.2453626