{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang L"],"funding":["Research Grants Council, University Grants Committee"],"pagination":["25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11770943"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural cells that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling on stem cells from human exfoliated deciduous teeth (SHED)-supported angiogenesis, focusing on its mechanism in PDGF-BB secretion. We also explored macrophages as an endogenous source of Sema4D for vascular stabilization.<h4>Methods</h4>The in vivo Matrigel plug angiogenesis assay was conducted to examine the impact of Sema4D on vessel formation and stabilization supported by SHED. Knockdown of Plexin-B1 in human umbilical vein endothelial cells (HUVECs) and PDGFR-β inhibitors were utilized to explore the fundamental regulatory mec"],"journal":["Stem cell research & therapy"],"pubmed_title":["Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization."],"pmcid":["PMC11770943"],"funding_grant_id":["General Research Fund: 17117619"],"pubmed_authors":["Liu J","Thalakiriyawa DS","Zhang L","Wang Y","Yang S","Dissanayaka WL"],"additional_accession":[]},"is_claimable":false,"name":"Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization.","description":"<h4>Background</h4>Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural cells that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling on stem cells from human exfoliated deciduous teeth (SHED)-supported angiogenesis, focusing on its mechanism in PDGF-BB secretion. We also explored macrophages as an endogenous source of Sema4D for vascular stabilization.<h4>Methods</h4>The in vivo Matrigel plug angiogenesis assay was conducted to examine the impact of Sema4D on vessel formation and stabilization supported by SHED. Knockdown of Plexin-B1 in human umbilical vein endothelial cells (HUVECs) and PDGFR-β inhibitors were utilized to explore the fundamental regulatory mec","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-18T16:49:55.623Z","creation":"2025-04-07T04:21:19.565Z"},"accession":"S-EPMC11770943","cross_references":{"pubmed":["39865283"],"doi":["10.1186/s13287-025-04149-0"]}}