biostudies-literatureShi SMinistry of Science and Technology of the People's Republic of ChinaGuangzhou Clinical Major Technology ProjectMinistry of Science and Technology of the People's Republic of ChinaSun Yat-Sen University Clinical Research 5010 Programe14939https://www.ebi.ac.uk/biostudies/studies/S-EPMC11771801biostudies-literatureUnknown27(1)Circulating lipids play a crucial role during pregnancy and may impact various pregnancy-related diseases. This study employed a two-sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associatJournal of clinical hypertension (Greenwich, Conn.)Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study.PMC117718012024P-ZD122021YFC27007002022003Zhao SFan YShi SWu FWang ZfalseMultidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study.Circulating lipids play a crucial role during pregnancy and may impact various pregnancy-related diseases. This study employed a two-sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associat2025-01-01T00:00:00Z2025 Jan2025-04-18T12:47:18.7Z2025-04-06T22:09:46.776ZS-EPMC117718013955022010.1111/jch.14939