{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Lyu D"],"pubmed_abstract":["<h4>Purpose</h4>To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen.<h4>Methods</h4>A young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of toad venom inoculation. He was diagnosed with a toxic cataract, and underwent phacoemulsification cataract surgery. Anterior capsule, nucleus, and cortex specimens from the patient (designated as PT_CAP, PT_PHACO, and PT_CTX, respectively) and age-related cataract controls (C_CAP, C_PHACO, and C_CTX, respectively) were collected and subjected to 4D label-free quantitative proteomics.<h4>Results</h4>A multitude of differentially expressed proteins (DEPs) were identified in the patie"],"journal":["Frontiers in medicine"],"pagination":["1537770"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772289"],"repository":["biostudies-literature"],"pubmed_title":["Ocular inoculation of toad venom: toxic cataract and proteomic profiling."],"pmcid":["PMC11772289"],"pubmed_authors":["Shi C","Feng Y","Lyu D","Ni S","Xu JW","Xu W","Xu J","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Ocular inoculation of toad venom: toxic cataract and proteomic profiling.","description":"<h4>Purpose</h4>To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen.<h4>Methods</h4>A young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of toad venom inoculation. He was diagnosed with a toxic cataract, and underwent phacoemulsification cataract surgery. Anterior capsule, nucleus, and cortex specimens from the patient (designated as PT_CAP, PT_PHACO, and PT_CTX, respectively) and age-related cataract controls (C_CAP, C_PHACO, and C_CTX, respectively) were collected and subjected to 4D label-free quantitative proteomics.<h4>Results</h4>A multitude of differentially expressed proteins (DEPs) were identified in the patie","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-08T19:52:32.218Z","creation":"2025-04-05T09:33:23.721Z"},"accession":"S-EPMC11772289","cross_references":{"pubmed":["39876868"],"doi":["10.3389/fmed.2024.1537770"]}}