biostudies-literatureUnknown11Lyu D<h4>Purpose</h4>To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen.<h4>Methods</h4>A young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of toad venom inoculation. He was diagnosed with a toxic cataract, and underwent phacoemulsification cataract surgery. Anterior capsule, nucleus, and cortex specimens from the patient (designated as PT_CAP, PT_PHACO, and PT_CTX, respectively) and age-related cataract controls (C_CAP, C_PHACO, and C_CTX, respectively) were collected and subjected to 4D label-free quantitative proteomics.<h4>Results</h4>A multitude of differentially expressed proteins (DEPs) were identified in the patieFrontiers in medicine1537770https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772289biostudies-literatureOcular inoculation of toad venom: toxic cataract and proteomic profiling.PMC11772289Shi CFeng YLyu DNi SXu JWXu WXu JZhu SfalseOcular inoculation of toad venom: toxic cataract and proteomic profiling.<h4>Purpose</h4>To report a singular case of cataract caused by toad venom inoculation and to scrutinize the pathological mechanisms through proteomic sequencing of the lens specimen.<h4>Methods</h4>A young Chinese male presented with progressively deteriorating vision in his right eye subsequent to a history of toad venom inoculation. He was diagnosed with a toxic cataract, and underwent phacoemulsification cataract surgery. Anterior capsule, nucleus, and cortex specimens from the patient (designated as PT_CAP, PT_PHACO, and PT_CTX, respectively) and age-related cataract controls (C_CAP, C_PHACO, and C_CTX, respectively) were collected and subjected to 4D label-free quantitative proteomics.<h4>Results</h4>A multitude of differentially expressed proteins (DEPs) were identified in the patie2024-01-01T00:00:00Z20242026-04-08T19:52:32.218Z2025-04-05T09:33:23.721ZS-EPMC117722893987686810.3389/fmed.2024.1537770