{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Yang M"],"pubmed_abstract":["<h4>Introduction</h4>Hepatic fibrosis (HF), a progressive chronic liver disease, is a serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There is growing evidence that natural products might provide safe and effective interventions for HF. Among them, rhaponticin (RHA), a stilbenoid glucoside natural product isolated from medicinal plants of <i>Rheum</i> L. of <i>Polygonaceae</i> Juss. has many pharmacological activities such as anti-inflammatory, antioxidant, antiproliferative, and antithrombotic properties. However, its effects on HF remain unclear.<h4>Methods</h4>Herein, we investigated the effects of RHA against HF on the carbon tetrachloride (CCl<sub>4</sub>)-induced hepatic fibrosis "],"journal":["Frontiers in pharmacology"],"pagination":["1505309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772292"],"repository":["biostudies-literature"],"pubmed_title":["Multi-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics."],"pmcid":["PMC11772292"],"pubmed_authors":["Zhang T","Yang M","Guo W","Lin W","Jiang D","Huang L","Peng L","Zhou Y","Zhao J","Wei Y","Hao YJ"],"additional_accession":[]},"is_claimable":false,"name":"Multi-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics.","description":"<h4>Introduction</h4>Hepatic fibrosis (HF), a progressive chronic liver disease, is a serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There is growing evidence that natural products might provide safe and effective interventions for HF. Among them, rhaponticin (RHA), a stilbenoid glucoside natural product isolated from medicinal plants of <i>Rheum</i> L. of <i>Polygonaceae</i> Juss. has many pharmacological activities such as anti-inflammatory, antioxidant, antiproliferative, and antithrombotic properties. However, its effects on HF remain unclear.<h4>Methods</h4>Herein, we investigated the effects of RHA against HF on the carbon tetrachloride (CCl<sub>4</sub>)-induced hepatic fibrosis ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-22T10:33:11.933Z","creation":"2025-04-22T10:33:11.933Z"},"accession":"S-EPMC11772292","cross_references":{"pubmed":["39877389"],"doi":["10.3389/fphar.2024.1505309"]}}