biostudies-literatureUnknown15Yang M<h4>Introduction</h4>Hepatic fibrosis (HF), a progressive chronic liver disease, is a serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There is growing evidence that natural products might provide safe and effective interventions for HF. Among them, rhaponticin (RHA), a stilbenoid glucoside natural product isolated from medicinal plants of <i>Rheum</i> L. of <i>Polygonaceae</i> Juss. has many pharmacological activities such as anti-inflammatory, antioxidant, antiproliferative, and antithrombotic properties. However, its effects on HF remain unclear.<h4>Methods</h4>Herein, we investigated the effects of RHA against HF on the carbon tetrachloride (CCl₄)-induced hepatic fibrosis Frontiers in pharmacology1505309https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772292biostudies-literatureMulti-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics.PMC11772292Zhang TYang MGuo WLin WJiang DHuang LPeng LZhou YZhao JWei YHao YJfalseMulti-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics.<h4>Introduction</h4>Hepatic fibrosis (HF), a progressive chronic liver disease, is a serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There is growing evidence that natural products might provide safe and effective interventions for HF. Among them, rhaponticin (RHA), a stilbenoid glucoside natural product isolated from medicinal plants of <i>Rheum</i> L. of <i>Polygonaceae</i> Juss. has many pharmacological activities such as anti-inflammatory, antioxidant, antiproliferative, and antithrombotic properties. However, its effects on HF remain unclear.<h4>Methods</h4>Herein, we investigated the effects of RHA against HF on the carbon tetrachloride (CCl₄)-induced hepatic fibrosis 2024-01-01T00:00:00Z20242025-04-22T10:33:11.933Z2025-04-22T10:33:11.933ZS-EPMC117722923987738910.3389/fphar.2024.1505309