{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shu H"],"funding":["NIA NIH HHS"],"pagination":["1481526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["<h4>Background</h4>Recent studies have shown that cerebrospinal fluid (CSF) levels of soluble triggering receptor expressed on myeloid cells 1 (sTREM1) are elevated in individuals with Alzheimer's disease (AD), though the relationship between CSF sTREM1 and hippocampal atrophy remains to be elucidated. The primary aim of this study was to investigate the association between CSF sTREM1 levels and longitudinal changes in hippocampal volumes, and to determine if this relationship is moderated by cognitive status.<h4>Methods</h4>We included 576 participants, comprising 152 cognitively unimpaired (CU) and 424 cognitively impaired (CI) individuals. In the cross-sectional analyses, Pearson's correlation tests were conducted to examine the relationship between baseline CSF sTREM1 levels and hippoc"],"journal":["Frontiers in aging neuroscience"],"pubmed_title":["Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults."],"pmcid":["PMC11772463"],"funding_grant_id":["R01 AG044546","P30 AG066444","U01 AG058922","RF1 AG074007","U01 AG024904","P01 AG026276","RF1 AG058501","P01 AG003991","RF1 AG053303"],"pubmed_authors":["Ding G","Huang X","Shu H","Xu X","He R"],"additional_accession":[]},"is_claimable":false,"name":"Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults.","description":"<h4>Background</h4>Recent studies have shown that cerebrospinal fluid (CSF) levels of soluble triggering receptor expressed on myeloid cells 1 (sTREM1) are elevated in individuals with Alzheimer's disease (AD), though the relationship between CSF sTREM1 and hippocampal atrophy remains to be elucidated. The primary aim of this study was to investigate the association between CSF sTREM1 levels and longitudinal changes in hippocampal volumes, and to determine if this relationship is moderated by cognitive status.<h4>Methods</h4>We included 576 participants, comprising 152 cognitively unimpaired (CU) and 424 cognitively impaired (CI) individuals. In the cross-sectional analyses, Pearson's correlation tests were conducted to examine the relationship between baseline CSF sTREM1 levels and hippoc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T23:10:55.37Z","creation":"2025-04-04T23:10:55.37Z"},"accession":"S-EPMC11772463","cross_references":{"pubmed":["39877076"],"doi":["10.3389/fnagi.2024.1481526"]}}