{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manzini V"],"funding":["Università degli Studi di Trento","Fondazione Valorizzazione Ricerca Trentina; University of Trento","Istituto Superiore di Sanità"],"pagination":["2573-2586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772464"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(2)"],"pubmed_abstract":["Despite the efforts to identify fluid biomarkers to improve diagnosis of Frontotemporal dementia (FTD), only a few candidates have been described in recent years. In a previous study, we identified three circulating miRNAs (miR-92a-3p, miR-320a and miR-320b) differentially expressed in FTD patients with respect to healthy controls and/or Alzheimer's disease (AD) patients. Now, we investigated whether those changes could be due to miRNAs contained in neuron-derived extracellular vesicles (NDEVs). We also evaluated miRNAs content in total plasma EVs and in CSF samples. The analysis of plasma NDEVs carried out on 40 subjects including controls (n = 13), FTD (n = 13) and AD (n = 14) patients, showed that both miR-92a-3p and miR-320a levels were triplicated in the FTD group if compared with CT "],"journal":["Molecular neurobiology"],"pubmed_title":["miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia."],"pmcid":["PMC11772464"],"funding_grant_id":["AB32 CUP I85H20000200005","BFC1"],"pubmed_authors":["Corbo M","Feligioni M","Manfredi F","Manzini V","Bruno G","Cappelletti P","Crestini A","Brentari I","Talarico G","Rivabene R","Puglielli L","Lo Giudice M","Rigby MJ","Orefice NS","Piscopo P","Denti MA"],"additional_accession":[]},"is_claimable":false,"name":"miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia.","description":"Despite the efforts to identify fluid biomarkers to improve diagnosis of Frontotemporal dementia (FTD), only a few candidates have been described in recent years. In a previous study, we identified three circulating miRNAs (miR-92a-3p, miR-320a and miR-320b) differentially expressed in FTD patients with respect to healthy controls and/or Alzheimer's disease (AD) patients. Now, we investigated whether those changes could be due to miRNAs contained in neuron-derived extracellular vesicles (NDEVs). We also evaluated miRNAs content in total plasma EVs and in CSF samples. The analysis of plasma NDEVs carried out on 40 subjects including controls (n = 13), FTD (n = 13) and AD (n = 14) patients, showed that both miR-92a-3p and miR-320a levels were triplicated in the FTD group if compared with CT ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-02T07:31:46.439Z","creation":"2025-04-03T23:58:14.705Z"},"accession":"S-EPMC11772464","cross_references":{"pubmed":["39138758"],"doi":["10.1007/s12035-024-04386-z"]}}