biostudies-literatureManzini VUniversità degli Studi di TrentoFondazione Valorizzazione Ricerca Trentina; University of TrentoIstituto Superiore di Sanità2573-2586https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772464biostudies-literatureUnknown62(2)Despite the efforts to identify fluid biomarkers to improve diagnosis of Frontotemporal dementia (FTD), only a few candidates have been described in recent years. In a previous study, we identified three circulating miRNAs (miR-92a-3p, miR-320a and miR-320b) differentially expressed in FTD patients with respect to healthy controls and/or Alzheimer's disease (AD) patients. Now, we investigated whether those changes could be due to miRNAs contained in neuron-derived extracellular vesicles (NDEVs). We also evaluated miRNAs content in total plasma EVs and in CSF samples. The analysis of plasma NDEVs carried out on 40 subjects including controls (n = 13), FTD (n = 13) and AD (n = 14) patients, showed that both miR-92a-3p and miR-320a levels were triplicated in the FTD group if compared with CT Molecular neurobiologymiR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia.PMC11772464AB32 CUP I85H20000200005BFC1Corbo MFeligioni MManfredi FManzini VBruno GCappelletti PCrestini ABrentari ITalarico GRivabene RPuglielli LLo Giudice MRigby MJOrefice NSPiscopo PDenti MAfalsemiR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia.Despite the efforts to identify fluid biomarkers to improve diagnosis of Frontotemporal dementia (FTD), only a few candidates have been described in recent years. In a previous study, we identified three circulating miRNAs (miR-92a-3p, miR-320a and miR-320b) differentially expressed in FTD patients with respect to healthy controls and/or Alzheimer's disease (AD) patients. Now, we investigated whether those changes could be due to miRNAs contained in neuron-derived extracellular vesicles (NDEVs). We also evaluated miRNAs content in total plasma EVs and in CSF samples. The analysis of plasma NDEVs carried out on 40 subjects including controls (n = 13), FTD (n = 13) and AD (n = 14) patients, showed that both miR-92a-3p and miR-320a levels were triplicated in the FTD group if compared with CT 2025-01-01T00:00:00Z2025 Feb2026-06-02T07:31:46.439Z2025-04-03T23:58:14.705ZS-EPMC117724643913875810.1007/s12035-024-04386-z