{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Dohi K"],"pubmed_abstract":["Cell therapy of skeletal muscles is a promising approach for the prevention of muscular diseases and age-related muscle atrophy. However, cell transplantation to treat muscle atrophy that does not involve disease, such as sarcopenia, is considered impossible because externally injected cells rarely engraft into non-injured muscle tissue. Additionally, skeletal muscle-specific somatic stem cells, called satellite cells, lose their ability to adhere to tissue after being cultured <i>in vitro</i> and transforming into myoblasts. To overcome these hurdles, we explored using extracellular matrix (ECM) components to create a niche environment conducive for myoblasts during transplantation. We demonstrated that myoblasts mixed with ECM components can be engrafted into intact skeletal muscle and s"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1502332"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772487"],"repository":["biostudies-literature"],"pubmed_title":["Achieving myoblast engraftment into intact skeletal muscle via extracellular matrix."],"pmcid":["PMC11772487"],"pubmed_authors":["Dohi K","Manabe Y","Fujii NL","Furuichi Y"],"additional_accession":[]},"is_claimable":false,"name":"Achieving myoblast engraftment into intact skeletal muscle via extracellular matrix.","description":"Cell therapy of skeletal muscles is a promising approach for the prevention of muscular diseases and age-related muscle atrophy. However, cell transplantation to treat muscle atrophy that does not involve disease, such as sarcopenia, is considered impossible because externally injected cells rarely engraft into non-injured muscle tissue. Additionally, skeletal muscle-specific somatic stem cells, called satellite cells, lose their ability to adhere to tissue after being cultured <i>in vitro</i> and transforming into myoblasts. To overcome these hurdles, we explored using extracellular matrix (ECM) components to create a niche environment conducive for myoblasts during transplantation. We demonstrated that myoblasts mixed with ECM components can be engrafted into intact skeletal muscle and s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T23:12:07.447Z","creation":"2025-04-04T23:12:07.447Z"},"accession":"S-EPMC11772487","cross_references":{"pubmed":["39877158"],"doi":["10.3389/fcell.2024.1502332"]}}