biostudies-literaturevan Lent DMUniversity Global Partnership fundThe Bill and Rebecca Reed Endowment for Precision Therapies and Palliative CareWilliam Castella family as William Castella Distinguished University Chair for Alzheimer's Disease ResearchNIA NIH HHSNHLBI NIH HHSAmerican Academy of Neurology Career Development AwardUSDA Agricultural Research Service AgreementNIDDK NIH HHSBarker Foundation as the Robert R. Barker Distinguished University Professor of Neurology, Psychiatry and Cellular and Integrative PhysiologyNINDS NIH HHSAlzheimer's AssociationInstitute for the Advancement of Food and Nutrition SciencesNIH HHSe14390https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772702biostudies-literatureUnknown21(1)<h4>Introduction</h4>We evaluated whether higher Dietary Inflammatory Index (DII) scores were associated with increased incidence of all-cause dementia and Alzheimer's disease (AD) dementia over 22.3 years of follow-up in the community-based Framingham Heart Study Offspring cohort.<h4>Methods</h4>One thousand four hundred eighty-seven participants (mean ± standard deviation, age in years 69 ± 6) completed food frequency questionnaires (FFQs) and had incident all-cause dementia and AD surveillance data available.<h4>Results</h4>Two hundred forty-six participants developed all-cause dementia (including AD, n = 187) over a median follow-up time of 13.1 years. Higher DII scores, averaged across a maximum of three timepoints, were associated with an increased incidence of all-cause dementia andAlzheimer's & dementia : the journal of the Alzheimer's AssociationAssociation between dietary inflammatory index score and incident dementia.PMC117727021P30AG066546-01A1R01AG033193N01-HC-25195RF1 AG059421R01AG054076R01AG059011-01A1R01 DK134533-01A1AARG-22-928604U01AG049505R03 AG067062R01 AG059011R01AG07747275N92019D00031R01-AG062531R01 AG079282R01 DK134533U01 AG058589R01 AG062531HHSN268201500001CR01AG079282AARF-22-918316R01 AG054076RF1AG059421R01AG049607R01 AG077472P30 AG066546R01 NS017950R03AG067062-01U01 AG052409L30 NS093634R01 AG04960758-8050-9-004U01AG052409R01 AG033193U01 AG049505NS017950L30NS093634HHSN268201500001IU01AG058589UH2 NS100605Jacques PFYuan CMesa HGSalinas JHimali JJJacob MEBeiser AGonzales MMvan Lent DMAparicio HJShort MISeshadri SfalseAssociation between dietary inflammatory index score and incident dementia.<h4>Introduction</h4>We evaluated whether higher Dietary Inflammatory Index (DII) scores were associated with increased incidence of all-cause dementia and Alzheimer's disease (AD) dementia over 22.3 years of follow-up in the community-based Framingham Heart Study Offspring cohort.<h4>Methods</h4>One thousand four hundred eighty-seven participants (mean ± standard deviation, age in years 69 ± 6) completed food frequency questionnaires (FFQs) and had incident all-cause dementia and AD surveillance data available.<h4>Results</h4>Two hundred forty-six participants developed all-cause dementia (including AD, n = 187) over a median follow-up time of 13.1 years. Higher DII scores, averaged across a maximum of three timepoints, were associated with an increased incidence of all-cause dementia and2025-01-01T00:00:00Z2025 Jan2025-04-04T14:04:43.17Z2025-04-04T14:04:43.17ZS-EPMC117727023964139010.1002/alz.14390