{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hammers DB"],"funding":["DOD ADNI","Lumosity","Pfizer Inc.","NIBIB NIH HHS","NIA NIH HHS","Alzheimer's Drug Discovery Foundation","Cogstate","IXICO Ltd.","Alzheimer's Association LEADS","Eisai Inc.","GE Healthcare","Eli Lilly and Company","CereSpir, Inc.","Fujirebio","Transition Therapeutics","Merck & Co., Inc.","Novartis Pharmaceuticals Corporation","Takeda Pharmaceutical Company","EuroImmun","Araclon Biotech","Meso Scale Diagnostics, LLC.","Servier","Alzheimer's Association","NIH HHS","Janssen Alzheimer Immunotherapy Research & Development, LLC.","Elan Pharmaceuticals, Inc.","Neurotrack Technologies","BioClinica, Inc.","AbbVie","Bristol-Myers Squibb Company","Piramal Imaging","Alzheimer's Disease Neuroimaging Initiative","NeuroRx Research","Genentech, Inc.","Biogen","Johnson & Johnson Pharmaceutical Research & Development LLC.","F. Hoffmann-La Roche Ltd","Lundbeck"],"pagination":["e14218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Introduction</h4>Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) share similar amyloid etiology, but evidence from smaller-scale studies suggests that they manifest differently clinically. Current analyses sought to contrast the cognitive profiles of EOAD and LOAD.<h4>Methods</h4>Z-score cognitive-domain composites for 311 amyloid-positive sporadic EOAD and 314 amyloid-positive LOAD participants were calculated from baseline data from age-appropriate control cohorts. Z-score composites were compared between AD groups for each domain.<h4>Results</h4>After controlling for cognitive status, EOAD displayed worse visuospatial, executive functioning, and processing speed/attention skills relative to LOAD, and LOAD displayed worse language, episodic immediate "],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI."],"pmcid":["PMC11772709"],"funding_grant_id":["P30 AG010133","P50 AG005146","U01 AG057195","U01AG6057195","P50 AG005681","AARG-22-926940","W81XWH-12-2-0012","P50 AG047366","U24 AG021886","R56 AG057195","U24AG021886","P30 AG072976","P30 AG066444","P50AG047366","P50 AG023501","LDRFP-21-818464","P30 AG013854","P50 AG008702","GENETICS-19-639372","P30 AG010124","P30 AG062421","P50 AG025688","U01 AG016976","P30 AG062422","P30 AG066506","P30AG066506","U24 AG072122","U01 AG024904"],"pubmed_authors":["Dage JL","Womack K","Apostolova LG","Musiek E","Salloway S","Beckett L","Day GS","Grant I","Taurone A","Turner RS","Clark D","Graff-Radford NR","Wolk DA","Lagarde J","Honig LS","Jones DT","Riddle M","Rogalski E","Carrillo MC","Reman R","Hammers DB","La Joie R","Rabinovici GD","Aisen P","Kirby K","Sha SJ","LEADS Consortium 1 for the Alzheimer's Disease Neuroimaging Initiative","Atri A","Nudelman K","Duara R","Eloyan A","Dickerson BC","Mendez MF","Wingo TS","Masdeu JC","Onyike CU","Polsinelli AJ","Johnson ECB","Thangarajah M","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.","description":"<h4>Introduction</h4>Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) share similar amyloid etiology, but evidence from smaller-scale studies suggests that they manifest differently clinically. Current analyses sought to contrast the cognitive profiles of EOAD and LOAD.<h4>Methods</h4>Z-score cognitive-domain composites for 311 amyloid-positive sporadic EOAD and 314 amyloid-positive LOAD participants were calculated from baseline data from age-appropriate control cohorts. Z-score composites were compared between AD groups for each domain.<h4>Results</h4>After controlling for cognitive status, EOAD displayed worse visuospatial, executive functioning, and processing speed/attention skills relative to LOAD, and LOAD displayed worse language, episodic immediate ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-04T23:12:12.572Z","creation":"2025-04-04T23:12:12.572Z"},"accession":"S-EPMC11772709","cross_references":{"pubmed":["39711228"],"doi":["10.1002/alz.14218"]}}