{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Wu L"],"pubmed_abstract":["Although an ongoing understanding of psoriasis vulgaris (PV) pathogenesis, little is known about the proteomic differences between moderate and severe psoriasis. In this cross-sectional study, we evaluated the proteomic differences between moderate and severe psoriasis using data-independent acquisition mass spectrometry (DIA-MS). 173 differentially expressed proteins (DEPs) were significantly differentially expressed between the two groups. Among them, 85 proteins were upregulated, while 88 were downregulated (FC ≥ ± 1.5, P < 0.05). Eighteen DEPs were mainly enriched in the IL - 17 signalling pathway, Neutrophil extracellular trap formation, Neutrophil degranulation and NF - kappa B signalling pathway, which were associated with psoriasis pathogenesis. Ingenuity pathway Analysis (IPA) ide"],"journal":["Scientific reports"],"pagination":["3387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772871"],"repository":["biostudies-literature"],"pubmed_title":["Cross-sectional study of proteomic differences between moderate and severe psoriasis."],"pmcid":["PMC11772871"],"pubmed_authors":["Cen C","Wu L","Huang J","Shen N","Hu L","Dong Q","Xie B"],"additional_accession":[]},"is_claimable":false,"name":"Cross-sectional study of proteomic differences between moderate and severe psoriasis.","description":"Although an ongoing understanding of psoriasis vulgaris (PV) pathogenesis, little is known about the proteomic differences between moderate and severe psoriasis. In this cross-sectional study, we evaluated the proteomic differences between moderate and severe psoriasis using data-independent acquisition mass spectrometry (DIA-MS). 173 differentially expressed proteins (DEPs) were significantly differentially expressed between the two groups. Among them, 85 proteins were upregulated, while 88 were downregulated (FC ≥ ± 1.5, P < 0.05). Eighteen DEPs were mainly enriched in the IL - 17 signalling pathway, Neutrophil extracellular trap formation, Neutrophil degranulation and NF - kappa B signalling pathway, which were associated with psoriasis pathogenesis. Ingenuity pathway Analysis (IPA) ide","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-22T10:27:14.602Z","creation":"2025-04-05T23:34:29.781Z"},"accession":"S-EPMC11772871","cross_references":{"pubmed":["39870771"],"doi":["10.1038/s41598-025-87252-9"]}}