{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bonate R"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["100693"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11772986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33"],"pubmed_abstract":["<h4>Background and purpose</h4>Quantitative MRI (qMRI) has been explored for detecting tumor changes during radiation therapy (RT) in head and neck squamous cell cancer (HNSCC). Clinical trials show prolonged survival with PD-1 targeted immune checkpoint inhibition. Hypofractionated radiation regimens are being studied to counteract radioresistant clonogen formation. This study aims to use daily qMRI monitoring in these therapies. The objective of this exploratory study was to investigate if qMRI can detect tumor microenvironment changes during hypofractionated RT in a phase I trial of Dose-Escalated Hypofractionated Adaptive Radiotherapy (DEHART).<h4>Materials and methods</h4>Seventeen subjects with advanced HNSCC underwent MR-guided RT with daily qMRI using a 15-fraction regimen to a cum"],"journal":["Physics and imaging in radiation oncology"],"pubmed_title":["Quantitative magnetic resonance imaging responses in head and neck cancer patients treated with magnetic resonance-guided hypofractionated radiation therapy."],"pmcid":["PMC11772986"],"funding_grant_id":["R21 CA256144","T32 GM080202"],"pubmed_authors":["Bonate R","Wong S","Paulson ES","Awan MJ","Tarima S","Shukla M","Himburg HA","Zenga J"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative magnetic resonance imaging responses in head and neck cancer patients treated with magnetic resonance-guided hypofractionated radiation therapy.","description":"<h4>Background and purpose</h4>Quantitative MRI (qMRI) has been explored for detecting tumor changes during radiation therapy (RT) in head and neck squamous cell cancer (HNSCC). Clinical trials show prolonged survival with PD-1 targeted immune checkpoint inhibition. Hypofractionated radiation regimens are being studied to counteract radioresistant clonogen formation. This study aims to use daily qMRI monitoring in these therapies. The objective of this exploratory study was to investigate if qMRI can detect tumor microenvironment changes during hypofractionated RT in a phase I trial of Dose-Escalated Hypofractionated Adaptive Radiotherapy (DEHART).<h4>Materials and methods</h4>Seventeen subjects with advanced HNSCC underwent MR-guided RT with daily qMRI using a 15-fraction regimen to a cum","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-07-15T11:08:37.87Z","creation":"2025-04-04T20:56:40.266Z"},"accession":"S-EPMC11772986","cross_references":{"pubmed":["39877149"],"doi":["10.1016/j.phro.2024.100693"]}}