biostudies-literatureUnknown14Yu C<h4>Objectives</h4>This study aimed to estimate the incidence of norovirus (NoV)-associated diarrhea and asymptomatic infections in children under 4 years of age and identify the genotypes of multiple NoV infections.<h4>Methods</h4>A community-based cohort study was conducted in Tarlac, Philippines. Children aged 0-2 years were followed up for 2 years. The prevalence and incidence rates of NoV-associated diarrhea and asymptomatic infections were calculated. Risk factors were assessed using the Cox proportional hazards model. The genotypes and immunotypes of repeated infections were tabulated.<h4>Results</h4>A total of 338 children aged 6208 child-months were analyzed. NoV was detected in 17.4% (84 of 527, 95% confidence interval [CI]: 12.7-19.7%) of diarrheal episodes and 10.8% (219 of 203IJID regions100549https://www.ebi.ac.uk/biostudies/studies/S-EPMC11773203biostudies-literatureNorovirus-associated diarrhea and asymptomatic infection in children aged under 4 years: a community-cohort study in the Philippines.PMC11773203Sayama YOkamoto MYu CSaito-Obata MKishi MCorpuz MCABonifacio JMOshitani HSaito MDapat CImamura TfalseNorovirus-associated diarrhea and asymptomatic infection in children aged under 4 years: a community-cohort study in the Philippines.<h4>Objectives</h4>This study aimed to estimate the incidence of norovirus (NoV)-associated diarrhea and asymptomatic infections in children under 4 years of age and identify the genotypes of multiple NoV infections.<h4>Methods</h4>A community-based cohort study was conducted in Tarlac, Philippines. Children aged 0-2 years were followed up for 2 years. The prevalence and incidence rates of NoV-associated diarrhea and asymptomatic infections were calculated. Risk factors were assessed using the Cox proportional hazards model. The genotypes and immunotypes of repeated infections were tabulated.<h4>Results</h4>A total of 338 children aged 6208 child-months were analyzed. NoV was detected in 17.4% (84 of 527, 95% confidence interval [CI]: 12.7-19.7%) of diarrheal episodes and 10.8% (219 of 2032025-01-01T00:00:00Z2025 Mar2025-04-04T23:12:12.214Z2025-04-04T23:12:12.214ZS-EPMC117732033987741610.1016/j.ijregi.2024.100549