biostudies-literatureUnknown333(10)SUNRRISE Trial Study GroupMedical Research Council<h4>Importance</h4>Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting.<h4>Objective</h4>To evaluate the effectiveness of iNPWT in reducing the rate of SSI in adults undergoing emergency laparotomy with primary skin closure.<h4>Design, setting, and participants</h4>SUNRRISE was an assessor-masked, pragmatic, phase 3, individual-participant, randomized clinical trial. Adult patients undergoing emergency laparotomy in 22 hospitals in the UK and 12 hospitals in Australia between December 18, 2018, and May 25, 2021, were recruited. Patients were followed up for 30 days postprocedure; database closure was on August 25, 2021.<hJAMA853-863https://www.ebi.ac.uk/biostudies/studies/S-EPMC11773404biostudies-literatureNegative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial.PMC11773404Fenton MStonelake SBesanko JDuffield JNoone TWilliams GChoi KSMcNally GChristie AHine RMartinez-Iglesias MDawe CAbulkhir AFilippa AWright DPatel MMcCormick RNinan PGarner SVarley RChern TYHall NVather RStaight SRattay TNewton KKnoblauch NKnowles KMcIlroy DSmart CJSilva NWassall HBajwa AGaraghty KPlatt KDrana AO'Sullivan SStorey SVissapragada RKroon HFitchett JRoy JStephensen BBlackmore ATraeger LNewton NHall COliveira Cunha MZhao JWong GChew KSayers AGupta SZhao BWillet JEgoroff NAfzal MASammour TOglesby AHickey LPremakumar YGhosh SStamatiou DBarnard PLoh EJLivingston CZaman SGanguly TArcher LUyen VO'Connor TMamunur Rahman MMelling SMcDonald RReynolds JNassar APalser TBughio MZain Butt HWiadji EMehta SPeters LMarriott PDavis AGlasbey JGricks BD'Aulerio GLewis MWilkinson LBall AFitzsimmons TCoe PDuberley SLun ECorrigan NJones LDumville JJowle DIqbal RSekhar HMcNeill CGhaneh PKeen ALun VMoug SSavage GRyan SKhasawneh FColley JStevens SLovelle Loh PVan de Ven LNnaji MLavigne JXinyi ZLott NBarbaro AJurat DAsokan GStanton SHeywood NOng DAngerami Almeida KDennis RVo UOng BJackson RRiddiough GBarreto SGMalik KWalsh NGriffiths BPorter JHardwick ARowland NShami SGoonawardhana DLiu DFuentes-Warr JGriffiths EArthur TPetersson JTimalapur SHudson DClark MPockney PAtherton KBiju ADuarte RRai GHunter DDudi-Venkata NTrinder MTopham KPenna KAhmed ASlade DDudi-Vankata NHaffenden VHuynh RMartin SCooke JHammill CTownley BAlbendary MMcMillan HPickering ORichardson JMarrs JWelch NBermingham HEdwards JTurnbull JHabeeb KAfzali HJohnston EBalance LNeal CDudi-Venkata NNDavies KPalacios APearce LByrne CHudig LClark SStokes CAmin KGelzinnis SLee MHaque IUMacutkiewicz CFaulkner GTownend POsborn LMason CTang HStott MBrailsford KHogben KRajamanickam SWolfenden HThomas VConvery KDawson AChang JWee MGomez Ruiz MFoo JWidjaja WCheung HIves NBlans ACurtis JZhou XElkawaga MBuckingham ECox DRankin ATran SCosta MBogdan MKonstantinou CRoberts KBarnett ARoberts JOngso YHossain TBrown ADi Sano SChadwick JKaur MDilworth MKennedy-Dalby ASadat MDuff SRees ABaker ALam YHBrown BAhmad AWatson DHerath MHussain THempenstall LRichards TTrivedi ATee YCMcAlpine LFatayer TPark SButcher DTan BHii AGrantham JNulty CSinha YO'Neill EGramlick MPodesta CAl-Khaddar ZHo WTan PLong BWhitehouse AYoussef FNair GLam AYassin NAWheldon LChugha AJoseph SKharodia TWard SClouston HSteele CRedfern JNarsey NHarrison BFong RSUNRRISE Trial Study GroupFish RBown EWilkin RHull RTorrance AHolmes MJoshi NImran Aslam MMohamed MMuralidharan VNg PAli MKhan EDilevska TKundu NSmith SMagill LBrown JBoddy ACampbell CNguyen ACampbell BKhan UYu LMBrown SSnelling SPinkney TfalseNegative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial.<h4>Importance</h4>Patients undergoing unplanned abdominal surgical procedures are at increased risk of surgical site infection (SSI). It is not known if incisional negative pressure wound therapy (iNPWT) can reduce SSI rates in this setting.<h4>Objective</h4>To evaluate the effectiveness of iNPWT in reducing the rate of SSI in adults undergoing emergency laparotomy with primary skin closure.<h4>Design, setting, and participants</h4>SUNRRISE was an assessor-masked, pragmatic, phase 3, individual-participant, randomized clinical trial. Adult patients undergoing emergency laparotomy in 22 hospitals in the UK and 12 hospitals in Australia between December 18, 2018, and May 25, 2021, were recruited. Patients were followed up for 30 days postprocedure; database closure was on August 25, 2021.<h2025-01-01T00:00:00Z2025 Mar2026-03-15T17:00:00.954Z2025-08-13T03:04:40.859ZS-EPMC117734043986933010.1001/jama.2024.24764