{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["Jiangsu Funding Program for Excellent Postdoctoral Talent","National Science and Technology Innovation 2030-Major Projects of Brain Science and Brain-Like Research","funding for Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing University","National Natural Science Foundation of China"],"pagination":["308-320"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11774012"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(2)"],"pubmed_abstract":["<h4>Objective</h4>The objective of this study was to investigate underlying mechanisms of long-term effective weight loss after laparoscopic sleeve gastrectomy (LSG) and effects on the medial orbitofrontal cortex (mOFC) and cognition.<h4>Methods</h4>A total of 18 individuals with obesity (BMI ≥ 30 kg/m<sup>2</sup>) underwent LSG. Clinical data, cognitive scores, and brain magnetic resonance imaging scans were evaluated before LSG and 12 months after LSG. We employed voxel-based morphometry analysis and seed-based resting-state functional connectivity (RSFC) analysis to assess LSG-induced structural and functional changes in mOFC. Partial correlation analysis and univariate and multivariate linear regression models were used to explore associations among biochemical indexes, neuroimaging, c"],"journal":["Obesity (Silver Spring, Md.)"],"pubmed_title":["Medial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy."],"pmcid":["PMC11774012"],"funding_grant_id":["2022ZD0211800","2022-LCYJ-MS-03","2022-LCYJ-PY-15","2022ZB694","82302172"],"pubmed_authors":["Zhang W","Li X","Zhu Z","Chen J","Zhang Z","Zhang X","Sun X","Zhang B","Bi Y","Duan Y"],"additional_accession":[]},"is_claimable":false,"name":"Medial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy.","description":"<h4>Objective</h4>The objective of this study was to investigate underlying mechanisms of long-term effective weight loss after laparoscopic sleeve gastrectomy (LSG) and effects on the medial orbitofrontal cortex (mOFC) and cognition.<h4>Methods</h4>A total of 18 individuals with obesity (BMI ≥ 30 kg/m<sup>2</sup>) underwent LSG. Clinical data, cognitive scores, and brain magnetic resonance imaging scans were evaluated before LSG and 12 months after LSG. We employed voxel-based morphometry analysis and seed-based resting-state functional connectivity (RSFC) analysis to assess LSG-induced structural and functional changes in mOFC. Partial correlation analysis and univariate and multivariate linear regression models were used to explore associations among biochemical indexes, neuroimaging, c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-18T16:47:39.956Z","creation":"2025-04-07T04:14:01.866Z"},"accession":"S-EPMC11774012","cross_references":{"pubmed":["39873400"],"doi":["10.1002/oby.24207"]}}